RAP1B (RAP1B, member of RAS oncogene family)

基因基本信息

基因基本信息

symbol:
RAP1B
locus group:
protein-coding gene
location:
12q15
gene_family:
RAS type family GTPases
alias symbol:
K-REV|RAL1B|DKFZp586H0723
alias name:
None
entrez id:
5908
ensembl gene id:
ENSG00000127314
ucsc gene id:
uc001suc.5
refseq accession:
NM_001010942
hgnc_id:
HGNC:9857
approved reserved:
1989-06-30

基因染色体位置

基因染色体位置

12q15

基因简述

基因简述

RAP1B（Ras-related protein Rap-1b）属于Ras超家族中的Rap亚家族，该家族还包括RAP1A、RAP2A、RAP2B等成员。RAP1B编码一种小GTP酶，在细胞信号传导中起关键作用，通过GTP/GDP结合状态切换调控下游通路。其主要功能包括参与细胞黏附、迁移、增殖和分化，尤其在整合素介导的细胞外基质相互作用中发挥核心作用。RAP1B通过激活效应蛋白如RIAM和Talin，促进整合素活化，从而影响细胞与基质的黏附强度。该基因在血小板活化、免疫细胞迁移及血管发育等生理过程中至关重要。RAP1B的突变可能导致功能异常，例如持续激活突变会增强细胞迁移能力，与肿瘤转移相关；而功能丧失突变则可能破坏整合素信号，导致出血倾向或免疫缺陷。研究发现RAP1B过表达与多种癌症（如乳腺癌、结直肠癌）的侵袭性增强有关，因其促进肿瘤细胞迁移和血管生成；相反，敲低RAP1B会抑制癌细胞转移但可能影响正常组织修复。RAP1B还与心血管疾病相关，其异常表达可能影响血管内皮功能。Rap基因家族的共性在于它们都是小GTP酶，通过GTP结合态（激活）和GDP结合态（失活）的转换调控多种细胞过程，且多数成员参与细胞骨架重组和细胞极性建立。RAP1B与RAP1A有89%的氨基酸同源性，但组织分布略有差异，RAP1B在血小板中含量尤为丰富。该基因还通过调控MAPK和PI3K/AKT等通路影响细胞存活信号。在神经系统，RAP1B参与突触可塑性调控，其表达异常可能与神经退行性疾病有关。最新研究还发现RAP1B在糖代谢调控中起作用，可能成为糖尿病治疗的潜在靶点。

中文English

该基??因编码在RAS状小GTP结合蛋白家族的一个成员。这个家族的成员调节多种细胞过程，包括细胞粘附和生长和分化。此蛋白质定位于细胞膜，并已显示出调节整合素介导的细胞信号传导。这种蛋白也起着调节由外向内的血小板信令的作用。选择性剪接结果在多个抄本变形。这个基因是假的[由RefSeq的，2011年10月提供] 6染色体3,5和9中

OMIM数据库中对RAP1B基因的介绍     Wikipedia数据库中对RAP1B基因的介绍

基因序列

基因序列

RAP1B基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY
41RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL
81 VYSITAQST FNDLQDLREQ ILRVKDTDDV PMILVGNKCD
121LEDERVVGKE QGQNLARQWN NCAFLESSAK SKINVNEIFY
161D LVRQINRK TPVPGKARKK SSCQLL
结构预测来自 AlphaFold DB（UniProt: P61224），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

RAP1B基因的碱基突变：           仅显示部分snp
rs734661       rs2277392       rs2431657       rs2439744       rs2439756       rs2439759       rs2468402       rs2468413       rs2468424       rs2468430       rs2920019       rs2920020       rs2920021       rs2920022       rs2952612       rs2956527       rs2956528      

基因表达

基因表达

RAP1B基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATTCCATCACAGCACAGTC
58
TCATTGGAACATCATCAGTGTC
59
CTGCTTTGGAGCAATTTACAG
58
TAAATGTGGACTGTGCTGTG
59
ATTCCATCACAGCACAGTC
58
TCATTGGAACATCATCAGTGTC
59
TAGTCGTTCTTGGCTCAGG
59
TGTAAATTGCTCCGTTCCTG
59
AGCGTGAGAGGTACTAGGT
59
CTTACCAAAGCAGACTTTCCA
59
ATTCCATCACAGCACAGTC
58
TCATTGGAACATCATCAGTGTC
59
CAGGAACGGAGCAATTTACAG
60
TCGTTAAATGTGGACTGTGC
59
ATTCCATCACAGCACAGTC
58
TCATTGGAACATCATCAGTGTC
59
ATTCCATCACAGCACAGTC
58
TCATTGGAACATCATCAGTGTC
59
GTGACAAGGATTGAAGTACTAGG
59
AAAGCAGACTTTCCAACGC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

RAP1B基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

RAP1B基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005525
B7ZB78 (UniProtKB)
IEA
GO:0005622
B7ZB78 (UniProtKB)
IEA
GO:0007264
B7ZB78 (UniProtKB)
IEA
GO:0016020
B7ZB78 (UniProtKB)
IEA
GO:0005525
E7ESV4 (UniProtKB)
IEA
GO:0005622
E7ESV4 (UniProtKB)
IEA
GO:0007264
E7ESV4 (UniProtKB)
IEA
GO:0016020
E7ESV4 (UniProtKB)
IEA
GO:0005525
F5GWU8 (UniProtKB)
IEA
GO:0005622
F5GWU8 (UniProtKB)
IEA
GO:0007264
F5GWU8 (UniProtKB)
IEA
GO:0016020
F5GWU8 (UniProtKB)
IEA
GO:0005525
F5GX62 (UniProtKB)
IEA
GO:0005622
F5GX62 (UniProtKB)
IEA
GO:0007264
F5GX62 (UniProtKB)
IEA
GO:0016020
F5GX62 (UniProtKB)
IEA
GO:0005525
F5GYB5 (UniProtKB)
IEA
GO:0005622
F5GYB5 (UniProtKB)
IEA
GO:0007264
F5GYB5 (UniProtKB)
IEA
GO:0016020
F5GYB5 (UniProtKB)
IEA
GO:0005525
F5GYH7 (UniProtKB)
IEA
GO:0005622
F5GYH7 (UniProtKB)
IEA
GO:0007264
F5GYH7 (UniProtKB)
IEA
GO:0016020
F5GYH7 (UniProtKB)
IEA
GO:0005525
F5GZG1 (UniProtKB)
IEA
GO:0005622
F5GZG1 (UniProtKB)
IEA
GO:0007264
F5GZG1 (UniProtKB)
IEA
GO:0016020
F5GZG1 (UniProtKB)
IEA
GO:0005525
F5H004 (UniProtKB)
IEA
GO:0005622
F5H004 (UniProtKB)
IEA
GO:0007264
F5H004 (UniProtKB)
IEA
GO:0016020
F5H004 (UniProtKB)
IEA
GO:0005525
F5H077 (UniProtKB)
IEA
GO:0005622
F5H077 (UniProtKB)
IEA
GO:0007264
F5H077 (UniProtKB)
IEA
GO:0016020
F5H077 (UniProtKB)
IEA
GO:0005525
F5H0B7 (UniProtKB)
IEA
GO:0005622
F5H0B7 (UniProtKB)
IEA
GO:0007264
F5H0B7 (UniProtKB)
IEA
GO:0016020
F5H0B7 (UniProtKB)
IEA
GO:0005525
F5H491 (UniProtKB)
IEA
GO:0005622
F5H491 (UniProtKB)
IEA
GO:0007264
F5H491 (UniProtKB)
IEA
GO:0016020
F5H491 (UniProtKB)
IEA
GO:0005525
F5H4H0 (UniProtKB)
IEA
GO:0005622
F5H4H0 (UniProtKB)
IEA
GO:0007264
F5H4H0 (UniProtKB)
IEA
GO:0016020
F5H4H0 (UniProtKB)
IEA
GO:0005525
F5H500 (UniProtKB)
IEA
GO:0005622
F5H500 (UniProtKB)
IEA
GO:0007264
F5H500 (UniProtKB)
IEA
GO:0016020
F5H500 (UniProtKB)
IEA
GO:0005525
F5H6R7 (UniProtKB)
IEA
GO:0005622
F5H6R7 (UniProtKB)
IEA
GO:0007264
F5H6R7 (UniProtKB)
IEA
GO:0016020
F5H6R7 (UniProtKB)
IEA
GO:0005525
F5H7Y6 (UniProtKB)
IEA
GO:0005622
F5H7Y6 (UniProtKB)
IEA
GO:0007264
F5H7Y6 (UniProtKB)
IEA
GO:0016020
F5H7Y6 (UniProtKB)
IEA
GO:0005525
F5H823 (UniProtKB)
IEA
GO:0005622
F5H823 (UniProtKB)
IEA
GO:0007264
F5H823 (UniProtKB)
IEA
GO:0016020
F5H823 (UniProtKB)
IEA
GO:0005525
F8WBC0 (UniProtKB)
IEA
GO:0005622
F8WBC0 (UniProtKB)
IEA
GO:0007264
F8WBC0 (UniProtKB)
IEA
GO:0016020
F8WBC0 (UniProtKB)
IEA
GO:0003924
P61224 (UniProtKB)
IDA
GO:0005515
P61224 (UniProtKB)
IPI
GO:0005515
P61224 (UniProtKB)
IPI
GO:0005515
P61224 (UniProtKB)
IPI
GO:0005515
P61224 (UniProtKB)
IPI
GO:0005515
P61224 (UniProtKB)
IPI
GO:0005515
P61224 (UniProtKB)
IPI
GO:0005515
P61224 (UniProtKB)
IPI
GO:0005525
P61224 (UniProtKB)
IDA
GO:0005622
P61224 (UniProtKB)
IDA
GO:0005811
P61224 (UniProtKB)
IDA
GO:0005829
P61224 (UniProtKB)
IDA
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005886
P61224 (UniProtKB)
TAS
GO:0005911
P61224 (UniProtKB)
IDA
GO:0016020
P61224 (UniProtKB)
TAS
GO:0016020
P61224 (UniProtKB)
TAS
GO:0019003
P61224 (UniProtKB)
IDA
GO:0032403
P61224 (UniProtKB)
IDA
GO:0032486
P61224 (UniProtKB)
IMP
GO:0061028
P61224 (UniProtKB)
IMP
GO:0070062
P61224 (UniProtKB)
IDA
GO:0070062
P61224 (UniProtKB)
IDA
GO:0070062
P61224 (UniProtKB)
IDA
GO:0071320
P61224 (UniProtKB)
IDA
GO:1901888
P61224 (UniProtKB)
IMP
GO:2000114
P61224 (UniProtKB)
IMP
GO:0030033
P61224 (UniProtKB)
IMP
GO:0045121
P61224 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 RAP1B基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Squamous cell carcinoma 0.003538676 3 0 BeFree_LHGDN
MYELODYSPLASTIC SYNDROME 0.00272435 1 0 LHGDN
Thyroid Neoplasm 0.002367032 1 0 GAD
Carcinoma, Papillary 0.002367032 1 0 GAD
Neoplasm Metastasis 0.000814326 3 0 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree
Central neuroblastoma 0.000271442 1 0 BeFree
Xenograft Model 0.000271442 1 0 BeFree
Pneumonia 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

Focal Adhesion Related Gene Signature for Glioma: The Pivotal Role of RAP1B in Disease Progression.
Wang N, Zhou H, Wang T, Wang Y, Wu W, Xiang J, Chen X, Zhang B, Wu P, Zhou M, Cao Y, Li X, Yu H, Bao G Curr Med Chem IF: 3.2 2026-03-31
Cancer‑associated fibroblast‑derived extracellular vesicles promote pancreatic cancer progression via the RAP1B/ANLN axis.
Yoshimori D, Kudo M, Ishino K, Ueda J, Shintani-Domoto Y, Matsushita A, Kawano Y, Ono T, Haruna T, Endo K, Hamaguchi A, Fujii T, Kawamoto Y, Teduka K, Kitamura T, Masamune A, Matsuda A, Yoshida H, Ohashi R Oncol Rep IF: 4.7 2026-10-00
TPST2-mediated tyrosine sulfation orchestrates porcine preimplantation development.
Gao J, Wang C, Xie H, Yang G, Yang Q, Huang C, Li S, Liu Z, He T, Yin Z, Jin JX, Wang J BMC Biol IF: 6.779 2026-01-22
Role of MIR-101-3P/RAP1B Axis and Insulin Protection in Glucose-Induced Stress in HK-2 Cell Model for Diabetic Kidney Disease.
Devaraju P, C Thambiah S, Ling KH, Zahari Sham SY Cell Biochem Biophys IF: 3.0 2026-06-00
Prenatal Diagnosis of Renal Anomalies Associated With a Novel Causative Variant in RAP1B Gene.
Cordisco A, Magliulo S, Di Marco C, Fortuna E, Terracciano A, Meloni C Clin Case Rep IF: 0.6 2026-03-00
Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass.
Simanshu DK, McCormick F Biochem J IF: 3.9 2026-05-06
The role of serum miR-28-5p in predicting diabetic retinopathy onset in type 2 diabetes.
Li J, Zhou Y, Wei L, Zhao Y, Wu M, Li C BMC Endocr Disord IF: 2.275 2026-04-22

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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