RHOA基因详情-基因数据库-基因云馆

RHOA (ras homolog family member A)

symbol:: RHOA
locus group:: protein-coding gene
location:: 3p21.31
gene_family:: Rho family GTPases
alias symbol:: Rho12|RHOH12
alias name:: None
entrez id:: 387
ensembl gene id:: ENSG00000067560
ucsc gene id:: uc003cwu.4
refseq accession:: NM_001664
hgnc_id:: HGNC:667
approved reserved:: 1990-03-19

3p21.31

RHOA（Ras homolog family member A）属于Rho GTPase家族，是小G蛋白超家族的重要成员，在细胞骨架重组、细胞迁移、增殖和基因表达调控等过程中发挥核心作用。RHOA通过GTP/GDP结合状态切换来调控下游信号通路，激活状态（GTP结合）可结合效应蛋白如ROCK（Rho-associated kinase）和mDia（哺乳动物Diaphanous相关蛋白），进而调节肌动蛋白应力纤维形成、细胞黏附和收缩。其主要作用位点包括细胞膜和胞质，通过与其他Rho家族成员（如RAC1、CDC42）协同调控细胞极性。RHOA突变（如G17V、L57V）可能导致组成性激活或功能丧失，与多种疾病相关：激活突变促进肿瘤侵袭转移（如胃癌、乳腺癌），而功能缺失突变可能影响心血管发育（如动脉导管未闭）。RHOA过表达会增强细胞迁移能力但抑制细胞周期进程，可能导致纤维化疾病或肿瘤转移；表达降低则破坏细胞连接（如上皮-间质转化受阻），影响胚胎发育（如神经嵴细胞迁移异常）。该基因与弥漫性大B细胞淋巴瘤（DLBCL）关系密切，约20%病例存在RHOA p.D120N突变。RHOA属于Rho基因家族（含20多个成员），家族共性为：均含GTP酶结构域，通过GTP水解循环调控细胞形态和运动；共享GEF（鸟苷酸交换因子）/GAP（GTP酶激活蛋白）调控系统；参与整合生长因子和黏附信号。在免疫系统中，RHOA还调控T细胞受体信号转导，其表达异常可能导致自身免疫疾病。最新研究发现RHOA在机械信号转导中起核心作用，能感知细胞外基质硬度并调控YAP/TAZ通路。药物开发中，针对RHOA-ROCK通路的抑制剂（如法舒地尔）已用于治疗脑血管痉挛和肺动脉高压。

中文English

无

OMIM数据库中对RHOA基因的介绍 Wikipedia数据库中对RHOA基因的介绍

RHOA基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE
41NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI
81
LMCFSIDSP DSLENIPEKW TPEVKHFCPN VPIILVGNKK
121DLRNDEHTRR ELAKMKQEPV KPEEGRDMAN RIGAFGYMEC
161S
AKTKDGVR EVFEMATRAA LQARRGKKKS GCLVL

结构预测来自 AlphaFold DB（UniProt: P61586），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

RHOA基因的碱基突变：仅显示部分snp

rs3448 rs8857 rs9609 rs14566 rs15932 rs3191115 rs3204561 rs3811698 rs3811699 rs8179163 rs8179164 rs8179165 rs8179166 rs11552757 rs41276541 rs72554687 rs76540530

RHOA基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GGAAAGCAGGTAGAGTTGG

GTATCTGGGTAGGAGAGGG

ATCGAGGTGGATGGAAAGC

CAGAAATGCTTGACTTCTGGG

CTTAACACCAACCACAGCAG

TCCACTATTGCTCAGGAGC

AGTTCCCAGAGGTGTATGTG

AGACTCTGTCTCTGCTTTCC

GGAAAGCAGGTAGAGTTGG

GTATCTGGGTAGGAGAGGG

TTCCCAGAGGTGTATGTGC

TTTCTGCTTTCCATCCACCT

GGAAAGCAGGTAGAGTTGG

GTATCTGGGTAGGAGAGGG

CAAGATGAAGCAGGAGCCT

TTAAATCTGGGAGGCGGAG

GAAAGCAGGTAGAGTTGGC

GTATCTGGGTAGGAGAGGG

TATCGAGGTGGATGGAAAGC

AGAAATGCTTGACTTCTGGG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

PTTG1

RHOA

Activation

22081074

STAT6

RHOA

Activation

19857574

RHOA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RHOA基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005525

C9JNR4 (UniProtKB)

IEA

GO:0005622

C9JNR4 (UniProtKB)

IEA

GO:0007264

C9JNR4 (UniProtKB)

IEA

GO:0005525

C9JRM1 (UniProtKB)

IEA

GO:0005622

C9JRM1 (UniProtKB)

IEA

GO:0007264

C9JRM1 (UniProtKB)

IEA

GO:0005525

C9JX21 (UniProtKB)

IEA

GO:0005622

C9JX21 (UniProtKB)

IEA

GO:0007264

C9JX21 (UniProtKB)

IEA

GO:0003924

P61586 (UniProtKB)

TAS

GO:0003924

P61586 (UniProtKB)

IDA

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005515

P61586 (UniProtKB)

IPI

GO:0005525

P61586 (UniProtKB)

IDA

GO:0005525

P61586 (UniProtKB)

IDA

GO:0005768

P61586 (UniProtKB)

IMP

GO:0005789

P61586 (UniProtKB)

TAS

GO:0005789

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

IDA

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005829

P61586 (UniProtKB)

TAS

GO:0005856

P61586 (UniProtKB)

IEA

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005886

P61586 (UniProtKB)

TAS

GO:0005925

P61586 (UniProtKB)

IDA

GO:0005938

P61586 (UniProtKB)

IDA

GO:0007179

P61586 (UniProtKB)

TAS

GO:0007266

P61586 (UniProtKB)

TAS

GO:0007266

P61586 (UniProtKB)

IDA

GO:0016032

P61586 (UniProtKB)

IEA

GO:0016477

P61586 (UniProtKB)

IMP

GO:0016477

P61586 (UniProtKB)

IDA

GO:0017022

P61586 (UniProtKB)

IPI

GO:0021762

P61586 (UniProtKB)

IEP

GO:0030027

P61586 (UniProtKB)

ISS

GO:0030036

P61586 (UniProtKB)

TAS

GO:0030054

P61586 (UniProtKB)

TAS

GO:0030054

P61586 (UniProtKB)

TAS

GO:0030054

P61586 (UniProtKB)

TAS

GO:0030054

P61586 (UniProtKB)

TAS

GO:0030054

P61586 (UniProtKB)

TAS

GO:0030054

P61586 (UniProtKB)

TAS

GO:0030168

P61586 (UniProtKB)

TAS

GO:0030334

P61586 (UniProtKB)

IMP

GO:0030496

P61586 (UniProtKB)

IEA

GO:0031234

P61586 (UniProtKB)

IDA

GO:0031532

P61586 (UniProtKB)

IMP

GO:0031982

P61586 (UniProtKB)

IDA

GO:0032467

P61586 (UniProtKB)

IMP

GO:0032467

P61586 (UniProtKB)

IMP

GO:0032956

P61586 (UniProtKB)

IDA

GO:0033688

P61586 (UniProtKB)

ISS

GO:0035385

P61586 (UniProtKB)

IDA

GO:0036089

P61586 (UniProtKB)

IDA

GO:0038027

P61586 (UniProtKB)

IMP

GO:0042346

P61586 (UniProtKB)

NAS

GO:0043123

P61586 (UniProtKB)

IEP

GO:0043149

P61586 (UniProtKB)

IMP

GO:0043296

P61586 (UniProtKB)

IDA

GO:0043297

P61586 (UniProtKB)

IMP

GO:0043542

P61586 (UniProtKB)

IGI

GO:0043931

P61586 (UniProtKB)

ISS

GO:0044319

P61586 (UniProtKB)

ISS

GO:0044319

P61586 (UniProtKB)

ISS

GO:0045666

P61586 (UniProtKB)

IMP

GO:0048010

P61586 (UniProtKB)

TAS

GO:0048013

P61586 (UniProtKB)

TAS

GO:0048015

P61586 (UniProtKB)

TAS

GO:0050771

P61586 (UniProtKB)

TAS

GO:0050772

P61586 (UniProtKB)

TAS

GO:0050919

P61586 (UniProtKB)

IMP

GO:0051056

P61586 (UniProtKB)

TAS

GO:0051496

P61586 (UniProtKB)

IDA

GO:0060071

P61586 (UniProtKB)

NAS

GO:0060071

P61586 (UniProtKB)

TAS

GO:0060193

P61586 (UniProtKB)

IDA

GO:0060193

P61586 (UniProtKB)

IMP

GO:0061383

P61586 (UniProtKB)

ISS

GO:0070062

P61586 (UniProtKB)

IDA

GO:0070062

P61586 (UniProtKB)

IDA

GO:0070062

P61586 (UniProtKB)

IDA

GO:0071902

P61586 (UniProtKB)

IDA

GO:0071944

P61586 (UniProtKB)

IMP

GO:0090051

P61586 (UniProtKB)

IGI

GO:0090307

P61586 (UniProtKB)

IMP

GO:0097498

P61586 (UniProtKB)

IGI

GO:1902766

P61586 (UniProtKB)

ISS

GO:1902766

P61586 (UniProtKB)

ISS

GO:1903673

P61586 (UniProtKB)

IMP

GO:2000145

P61586 (UniProtKB)

TAS

GO:0032154

P61586 (UniProtKB)

IDA

可能调控 RHOA基因的相关microRNA：

hsa-miR-124 hsa-miR-375 hsa-miR-10b hsa-miR-10b* hsa-miR-122 hsa-miR-122* hsa-miR-31 hsa-miR-31* hsa-miR-133a hsa-miR-155

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4310 Wnt signaling pathway [PATH:hsa04310]
4350 TGF-beta signaling pathway [PATH:hsa04350]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4024 cAMP signaling pathway [PATH:hsa04024]
4022 cGMP - PKG signaling pathway [PATH:hsa04022]
4144 Endocytosis [PATH:hsa04144]
4810 Regulation of actin cytoskeleton [PATH:hsa04810]
4510 Focal adhesion [PATH:hsa04510]
4520 Adherens junction [PATH:hsa04520]
4530 Tight junction [PATH:hsa04530]
4611 Platelet activation [PATH:hsa04611]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4670 Leukocyte transendothelial migration [PATH:hsa04670]
4062 Chemokine signaling pathway [PATH:hsa04062]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4270 Vascular smooth muscle contraction [PATH:hsa04270]
4972 Pancreatic secretion [PATH:hsa04972]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4360 Axon guidance [PATH:hsa04360]
5200 Pathways in cancer [PATH:hsa05200]
5206 MicroRNAs in cancer [PATH:hsa05206]
5205 Proteoglycans in cancer [PATH:hsa05205]
5203 Viral carcinogenesis [PATH:hsa05203]
5210 Colorectal cancer [PATH:hsa05210]
5130 Pathogenic Escherichia coli infection [PATH:hsa05130]
5133 Pertussis [PATH:hsa05133]
5152 Tuberculosis [PATH:hsa05152]
5100 Bacterial invasion of epithelial cells [PATH:hsa05100]

名称
Axon guidance
Axonal growth inhibition (RHOA activation)
Axonal growth stimulation
beta-catenin independent WNT signaling
Developmental Biology
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
G alpha (12/13) signalling events
G beta:gamma signalling through PI3Kgamma
G-protein beta:gamma signalling
GPCR downstream signaling
GPVI-mediated activation cascade
Hemostasis
NGF signalling via TRKA from the plasma membrane
p75 NTR receptor-mediated signalling
p75NTR regulates axonogenesis
PCP/CE pathway
PI3K/AKT activation
Platelet activation, signaling and aggregation
Rho GTPase cycle
RHO GTPase Effectors
RHO GTPases activate CIT
RHO GTPases Activate Formins
RHO GTPases activate KTN1
RHO GTPases activate PKNs
RHO GTPases Activate Rhotekin and Rhophilins
RHO GTPases Activate ROCKs
Sema4D in semaphorin signaling
Sema4D induced cell migration and growth-cone collapse
Sema4D mediated inhibition of cell attachment and migration
Semaphorin interactions
Signaling by GPCR
Signaling by Rho GTPases
Signaling by TGF-beta Receptor Complex
Signaling by VEGF
Signaling by Wnt
Signalling by NGF
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFA-VEGFR2 Pathway

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Stomach Neoplasms	0.1254487	4	0	CTD_human_LHGDN
IGA Glomerulonephritis	0.12272435	2	0	CTD_human_LHGDN
Angioimmunoblastic Lymphadenopathy	0.121357209	5	3	BeFree_CTD_human
Peripheral T-Cell Lymphoma	0.120814326	4	3	BeFree_CTD_human
T-Cell Lymphoma	0.120271442	1	0	BeFree_CTD_human
Neoplasm Invasiveness	0.12	1	0	CTD_human
Lymphoma, T-Cell, Cutaneous	0.12	1	0	CTD_human
Proteinuria	0.12	1	0	CTD_human
Bladder Neoplasm	0.12	1	0	CTD_human
Fibrosis	0.08272435	2	0	LHGDN_RGD

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RHOA (ras homolog family member A)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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