RPS14基因详情-基因数据库-基因云馆

RPS14 (ribosomal protein S14)

symbol:: RPS14
locus group:: protein-coding gene
location:: 5q33.1
gene_family:: S ribosomal proteins
alias symbol:: EMTB|S14
alias name:: emetine resistance|40S ribosomal...
entrez id:: 6208
ensembl gene id:: ENSG00000164587
ucsc gene id:: uc003lsi.4
refseq accession:: NM_001025071
hgnc_id:: HGNC:10387
approved reserved:: 2001-06-22

5q33.1

RPS14（核糖体蛋白S14）是核糖体小亚基40S的一个组成部分，属于核糖体蛋白（Ribosomal Proteins, RPs）基因家族。核糖体蛋白家族是一组高度保守的蛋白质，共同参与核糖体的组装和蛋白质翻译过程，对维持细胞正常功能至关重要。RPS14在核糖体中负责稳定rRNA结构并协助mRNA的准确解码，直接影响蛋白质合成的效率和准确性。该基因的主要作用位点是细胞质中的核糖体，其表达产物与其他核糖体蛋白及rRNA相互作用，共同完成翻译过程。RPS14的突变可能导致核糖体组装缺陷或功能异常，进而引发翻译错误或效率下降，影响细胞增殖和存活。研究发现，RPS14单倍体不足（haploinsufficiency）与5q-综合征（一种骨髓增生异常综合征）密切相关，患者表现为贫血和造血功能障碍，原因是RPS14表达降低导致红系祖细胞分化受阻。若RPS14过表达，可能干扰核糖体平衡，引发核应激反应（ribosomal stress），激活p53通路并诱导细胞凋亡；而表达降低则会导致核糖体生物发生（ribosome biogenesis）缺陷，影响快速增殖的细胞（如造血细胞）。此外，RPS14还参与调控其他基因的表达，例如通过影响翻译效率间接改变癌基因或抑癌基因的蛋白水平。该基因家族（RPs）的共性包括：高度保守的序列、在翻译中的核心作用、与rRNA的紧密结合能力，以及突变后常导致核糖体病（ribosomopathies）如Diamond-Blackfan贫血等。RPS14的功能研究为理解核糖体相关疾病和靶向治疗提供了重要线索。

中文English

核糖体，催化蛋白质合成的细胞器，由一个小40S亚基和60S大亚基。一起这些亚基组成的4 RNA种类和大约80结构不同的蛋白质。该基因编码一种核糖体蛋白，它是40S亚基的一个组成部分。该蛋白属于S11P家族核糖体的蛋白质。它位于细胞质中。利用替代转录起始位点的转录变体在文献中已有描述。作为典型编码核糖体蛋白的基因，有该基因通过基因组分散的多个经处理的假基因。在中国仓鼠卵巢细胞，在该基因的突变可导致抗吐根碱，蛋白质合成抑制剂。已发现了该基因编码的蛋白质相同的多个可变剪接转录变异体。 [由RefSeq的，2008年7月提供]

OMIM数据库中对RPS14基因的介绍 Wikipedia数据库中对RPS14基因的介绍

RPS14基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT
41FVHVTDLSGK ETICRVTGGM KVKADRDESS PYAAMLAAQD
81
VAQRCKELG ITALHIKLRA TGGNRTKTPG PGAQSALRAL
121ARSGMKIGRI EDVTPIPSDS TRRKGGRRGR RL

结构预测来自 AlphaFold DB（UniProt: P62263），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

RPS14基因的碱基突变：仅显示部分snp

rs4841 rs2070840 rs2070841 rs2070842 rs2070843 rs2070844 rs2073472 rs2545347 rs2748240 rs2748241 rs2748242 rs2748243 rs3187814 rs3797622 rs3819332 rs11354876 rs11538773

RPS14基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CCACAGGAGGAAATAGGACC

60

CCCGATCTTCATACCCGAG

60

TCTTTCTGGCAAGGAAACC

58

GCATATGGTGAGGATTCATCTC

59

TCTTTCTGGCAAGGAAACC

58

GCATATGGTGAGGATTCATCTC

59

TCTTTCTGGCAAGGAAACC

58

GCATATGGTGAGGATTCATCTC

59

TCTTTCTGGCAAGGAAACC

58

GCATATGGTGAGGATTCATCTC

59

CCACAGGAGGAAATAGGACC

59

CCCGATCTTCATACCCGAG

59

CCACAGGAGGAAATAGGACC

60

CCCGATCTTCATACCCGAG

60

TCTTTCTGGCAAGGAAACC

58

GCATATGGTGAGGATTCATCTC

59

ATCTTTCTGGCAAGGAAACC

59

CATATGGTGAGGATTCATCTCG

59

ATCTTTCTGGCAAGGAAACC

59

CATATGGTGAGGATTCATCTCG

59

尚未收录相关数据

RPS14基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RPS14基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0003735

E5RH77 (UniProtKB)

IEA

GO:0005840

E5RH77 (UniProtKB)

IEA

GO:0006412

E5RH77 (UniProtKB)

IEA

GO:0003735

H0YB22 (UniProtKB)

IEA

GO:0005840

H0YB22 (UniProtKB)

IEA

GO:0006412

H0YB22 (UniProtKB)

IEA

GO:0000028

P62263 (UniProtKB)

ISS

GO:0000028

P62263 (UniProtKB)

IMP

GO:0000122

P62263 (UniProtKB)

IDA

GO:0000184

P62263 (UniProtKB)

TAS

GO:0000462

P62263 (UniProtKB)

IBA

GO:0003723

P62263 (UniProtKB)

ISS

GO:0003735

P62263 (UniProtKB)

IBA

GO:0005515

P62263 (UniProtKB)

IPI

GO:0005515

P62263 (UniProtKB)

IPI

GO:0005654

P62263 (UniProtKB)

TAS

GO:0005654

P62263 (UniProtKB)

TAS

GO:0005654

P62263 (UniProtKB)

TAS

GO:0005654

P62263 (UniProtKB)

TAS

GO:0005654

P62263 (UniProtKB)

TAS

GO:0005730

P62263 (UniProtKB)

IDA

GO:0005737

P62263 (UniProtKB)

IDA

GO:0005739

P62263 (UniProtKB)

IEA

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005829

P62263 (UniProtKB)

TAS

GO:0005925

P62263 (UniProtKB)

IDA

GO:0006364

P62263 (UniProtKB)

TAS

GO:0006412

P62263 (UniProtKB)

IC

GO:0006412

P62263 (UniProtKB)

IMP

GO:0006412

P62263 (UniProtKB)

IC

GO:0006412

P62263 (UniProtKB)

IC

GO:0006413

P62263 (UniProtKB)

TAS

GO:0006417

P62263 (UniProtKB)

IEA

GO:0006614

P62263 (UniProtKB)

TAS

GO:0016020

P62263 (UniProtKB)

IDA

GO:0019083

P62263 (UniProtKB)

TAS

GO:0022627

P62263 (UniProtKB)

IDA

GO:0022627

P62263 (UniProtKB)

IDA

GO:0022627

P62263 (UniProtKB)

IDA

GO:0030218

P62263 (UniProtKB)

IMP

GO:0030490

P62263 (UniProtKB)

ISS

GO:0044822

P62263 (UniProtKB)

IDA

GO:0045182

P62263 (UniProtKB)

IMP

GO:0048027

P62263 (UniProtKB)

IDA

GO:0070062

P62263 (UniProtKB)

IDA

GO:0070062

P62263 (UniProtKB)

IDA

GO:0070181

P62263 (UniProtKB)

IBA

可能调控 RPS14基因的相关microRNA：

hsa-miR-145 hsa-miR-145* hsa-miR-106b hsa-miR-181d hsa-miR-25 hsa-miR-331-3p hsa-miR-484 hsa-miR-744 hsa-miR-92a hsa-miR-92b

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
3010 Ribosome [PATH:hsa03010]

名称
3' -UTR-mediated translational regulation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Disease
Eukaryotic Translation Elongation
Eukaryotic Translation Initiation
Eukaryotic Translation Termination
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Gene Expression
GTP hydrolysis and joining of the 60S ribosomal subunit
Infectious disease
Influenza Infection
Influenza Life Cycle
Influenza Viral RNA Transcription and Replication
L13a-mediated translational silencing of Ceruloplasmin expression
Metabolism of proteins
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Peptide chain elongation
Ribosomal scanning and start codon recognition
SRP-dependent cotranslational protein targeting to membrane
Translation
Translation initiation complex formation
Viral mRNA Translation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
5q-syndrome	0.245157396	19	0	BeFree_CTD_human_ORPHANET
Animal Mammary Neoplasms	0.12	1	0	CTD_human
Anoxia	0.12	1	0	CTD_human
Mammary Neoplasms, Experimental	0.12	1	0	CTD_human
Myelodysplastic Syndrome with Isolated del(5q)	0.005157396	19	0	BeFree
Chromosome 5, trisomy 5q	0.005157396	19	0	BeFree
Anemia, Diamond-Blackfan	0.003995683	7	0	BeFree_GAD
Malignant neoplasm of breast	0.001085767	4	0	BeFree
Anemia, Macrocytic	0.001085767	4	0	BeFree
Preleukemia	0.000814326	3	0	BeFree

Organellar genome evolution in Camellia tianeensis (Theaceae): comparative insights into RNA editing, codon usage, and DNA transfer between chloroplast and mitochondrion.

Ran Z, Li Z, Xiao X, Gu W, An M, Xu J, Guo Z BMC Genomics IF: 3.9 2026-02-07

De novo assembly of the first mitochondrial genome in Benincasa reveals structural dynamics and evolutionary insights in Cucurbitaceae.

Zhang K, Zhang H, Huang Z, Liu X, Zhang B, Shan X, Fan W, Wang C BMC Plant Biol IF: 5.6 2026-02-11

Cloning, expression, and purification of small subunit human ribosomal proteins SA/uS2, S2/uS5, S3/uS3, S7/eS7, S8/eS8, S12/eS12, S13/uS15, and S14/uS11 for in vitro characterization.

Nicholl S, Thompson M, Goshtasbi-Gowharrizi A, Streit J, Martin J, Outmezguine D, Charkhabi A, Zeidan Q MicroPubl Biol None

Comparative Analysis of Chloroplast Genomes Reveals Molecular Evolution and Phylogenetic Relationships in Fraxinus (Fraxinus mandshurica).

Liu W, Wu J, Zheng H, Qu G, Wang S Int J Mol Sci IF: 3.226 2026-09-06

RPS14 as an aging-related biomarker for early-onset alterations of testicular senescence-associated genes in spermatogenic dysfunction at childbearing age.

Dong F, Ping P, Wang SQ, Ma Y, Chen XF J Gerontol A Biol Sci Med Sci IF: 4.6 2026-03-10

Assembly, Characterization and Comparative Analysis of the Complete Mitogenome of Small-Leaved Eriobotrya seguinii (Maleae, Rosaceae).

Idrees M, Safiul Azam FM, Li M, Zhang Z, Wang H, Lv Y Genes (Basel) IF: 3.600 2026-01-20

Sni445 recruits box C/D snoRNPs snR4 and snR45 to guide ribosomal RNA acetylation by Kre33.

Hafner J, Zierler I, Hamze H, Favre S, Thoms M, Kunowska N, Rimser S, Albert B, Caetano T, Aguirrebengoa M, Beckmann R, Stelzl U, Kressler D, Henras AK, Pertschy B Nucleic Acids Res IF: 15.0 2026-01-22

Genome-wide characterization of the PPR gene family and its potential roles in stress responses and chloroplast RNA editing in Brassica rapa.

Zhang J, Chen M, Zhang J, Hu F, Su K, Zhi Y, Huang Y, Hu J, Tian Z, Yang Q, Li W, Xu K, Zhou F Front Plant Sci IF: 5.9 None

Comprehensive plastid phylogenomics reveal the phylogeny of Amomum s.l. (Zingiberaceae) from Peninsular Malaysia.

Fareed FS, Singaram N, Abdul Malek AZ, Hashim AM, Sam YY, Hin OI PhytoKeys IF: 1.6 None

Comparative genomics, phylogenomic reconstruction and divergence time analysis of 32 Delphinium species based on complete chloroplast genomes.

Lv T, Zhang Y, Guo L, Hu X, Ju J, Tang N Front Plant Sci IF: 5.9 2026-00-00

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RPS14 (ribosomal protein S14)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

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