RPS3 (ribosomal protein S3)

基因基本信息

基因基本信息

symbol:
RPS3
locus group:
protein-coding gene
location:
11q13.4
gene_family:
S ribosomal proteins
alias symbol:
FLJ26283|FLJ27450|MGC87870|S3
alias name:
IMR-90 ribosomal protein S3|40S ...
entrez id:
6188
ensembl gene id:
ENSG00000149273
ucsc gene id:
uc031qcu.2
refseq accession:
NM_001005
hgnc_id:
HGNC:10420
approved reserved:
1994-12-02

基因染色体位置

基因染色体位置

11q13.4

基因简述

基因简述

RPS3（核糖体蛋白S3）是核糖体40S小亚基的组成部分，属于RPS基因家族（核糖体蛋白家族），该家族成员普遍参与核糖体组装和蛋白质翻译过程。RPS3在细胞质中与rRNA结合形成核糖体复合体，直接参与mRNA解码和蛋白质合成，但其功能不仅限于此——它还具有DNA修复活性（能识别并切除紫外线诱导的嘧啶二聚体）和调控凋亡的作用（通过影响NF-κB信号通路）。该基因在几乎所有组织中均有基础表达，尤其在增殖活跃的细胞中表达较高。当RPS3发生突变时，可能导致核糖体功能异常，引发翻译效率下降或错误蛋白合成，与戴蒙德-布莱克范贫血（Diamond-Blackfan anemia，一种核糖体病）和多种癌症（如结直肠癌、肝癌）相关。其过表达会通过NF-κB通路促进细胞增殖和抗凋亡，常见于肿瘤组织；而低表达则导致核糖体应激（ribosome stress），触发p53介导的细胞周期阻滞或凋亡。RPS基因家族的共性包括：高度保守的序列、参与核糖体生物发生（ribosome biogenesis）、部分成员具有"兼职功能"（moonlighting function，指除翻译外其他功能）。例如RPS3的DNA修复能力就属于典型兼职功能。该基因还与病毒感染相关，某些病毒会劫持RPS3促进自身蛋白合成。需要注意"核糖体病"（ribosomopathy）这一概念，指核糖体蛋白或rRNA异常导致的一类疾病，常表现为造血障碍和癌症易感性。

中文English

核糖体，催化蛋白质合成的细胞器，由一个小40S亚基和60S大亚基。一起这些亚基组成的4 RNA种类和大约80结构不同的蛋白质。该基因编码一种核糖体蛋白，它是40S亚基，在那里形成，其中翻译是发起域的一部分的组分。该蛋白属于S3P家族核糖体的蛋白质。已经在小鼠和大鼠蛋白的研究表明，该蛋白质具有如参与UV诱导的DNA损伤的修复核酸内切酶的extraribosomal作用。该蛋白质似乎是位于核仁细胞质和细胞核，但不能同时使用。该基因在结肠腺癌和腺瘤性息肉相比邻近的正常结肠粘膜的表达更高水平已经观察到。该基因是共转录的小核仁RNA基因U15A和U15B，它们分别位于其第一和第五内含子。作为典型编码核糖体蛋白的基因，有该基因通过基因组分散的多个经处理的假基因。已发现该基因编码不同亚型多重选择性剪接转录变异体。 [由RefSeq的，2012年5月提供]

OMIM数据库中对RPS3基因的介绍     Wikipedia数据库中对RPS3基因的介绍

基因序列

基因序列

RPS3基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR
41VTPTRTEIII LATRTQNVLG EKGRRIRELT AVVQKRFGFP
81 EGSVELYAE KVATRGLCAI AQAESLRYKL LGGLAVRRAC
121YGVLRFIMES GAKGCEVVVS GKLRGQRAKS MKFVDGLMIH
161S GDPVNYYV DTAVRHVLLR QGVLGIKVKI MLPWDPTGKI
201GPKKPLPDHV SIVEPKDEIL PTTPISEQKG GKPEPPAMPQ
241PV PTA
结构预测来自 AlphaFold DB（UniProt: P23396），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

RPS3基因的碱基突变：           仅显示部分snp
rs11236425       rs11236426       rs11539810       rs77761323       rs138126692       rs143670546       rs147393088       rs182453601       rs186902058       rs201073930       rs201608126       rs201857455       rs370183834       rs370558687       rs370786483       rs371260219       rs371918072      

基因表达

基因表达

RPS3基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATTATCTTAGCCACCAGGGC
59
CTCTGTCCTCGGAGTTTCC
59
CCATCTCAGAACAGAAGGGT
59
CAAGGAGACCCTGTTATGCT
60
GAAGAGGAAGTTTGTCGCTG
59
GAGTAGCCATCTTCAGCCA
59
CCATCTCAGAACAGAAGGGT
59
CAAGGAGACCCTGTTATGCT
60
TGTAGTTCAGAAGAGGTCTGTG
60
ACTCTCCATGATGAACCGC
60
ATGTTCTTGGTGAGAAGGG
57
TTCCACAATGCTCTACACTG
58
GGCAGTGTAGAGCTTTATGC
59
GTTTGTAACGCAGAGACTCTG
59
GGCAGTGTAGAGCTTTATGC
59
GTTTGTAACGCAGAGACTCTG
59
AGTAAACGTGTTTGTCGCTG
60
GAGTAGCCATCTTCAGCCA
59
CCAGGACAGAAATCATTATCTTAGC
60
TCTCCATGATGAACCGCAG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

RPS3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

RPS3基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003723
E9PJH4 (UniProtKB)
IEA
GO:0003735
E9PJN9 (UniProtKB)
IEA
GO:0005840
E9PJN9 (UniProtKB)
IEA
GO:0006412
E9PJN9 (UniProtKB)
IEA
GO:0003723
E9PK82 (UniProtKB)
IEA
GO:0003723
E9PL09 (UniProtKB)
IEA
GO:0003735
E9PL09 (UniProtKB)
IEA
GO:0005737
E9PL09 (UniProtKB)
IDA
GO:0006412
E9PL09 (UniProtKB)
IEA
GO:0015935
E9PL09 (UniProtKB)
IEA
GO:0003723
E9PPU1 (UniProtKB)
IEA
GO:0005737
E9PPU1 (UniProtKB)
IDA
GO:0003723
E9PQ96 (UniProtKB)
IEA
GO:0003735
E9PSF4 (UniProtKB)
IEA
GO:0005737
E9PSF4 (UniProtKB)
IDA
GO:0005840
E9PSF4 (UniProtKB)
IEA
GO:0006412
E9PSF4 (UniProtKB)
IEA
GO:0003723
F2Z2S8 (UniProtKB)
IEA
GO:0003723
H0YCJ7 (UniProtKB)
IEA
GO:0003723
H0YEU2 (UniProtKB)
IEA
GO:0003735
H0YEU2 (UniProtKB)
IEA
GO:0005840
H0YEU2 (UniProtKB)
IEA
GO:0006412
H0YEU2 (UniProtKB)
IEA
GO:0003723
H0YF32 (UniProtKB)
IEA
GO:0000184
P23396 (UniProtKB)
TAS
GO:0003677
P23396 (UniProtKB)
IDA
GO:0003684
P23396 (UniProtKB)
IDA
GO:0003684
P23396 (UniProtKB)
IDA
GO:0003684
P23396 (UniProtKB)
IDA
GO:0003684
P23396 (UniProtKB)
IDA
GO:0003723
P23396 (UniProtKB)
IDA
GO:0003729
P23396 (UniProtKB)
IDA
GO:0003735
P23396 (UniProtKB)
IDA
GO:0003735
P23396 (UniProtKB)
NAS
GO:0003906
P23396 (UniProtKB)
IDA
GO:0003906
P23396 (UniProtKB)
IDA
GO:0003906
P23396 (UniProtKB)
IDA
GO:0003906
P23396 (UniProtKB)
IDA
GO:0003906
P23396 (UniProtKB)
IDA
GO:0004520
P23396 (UniProtKB)
IDA
GO:0004520
P23396 (UniProtKB)
IDA
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005515
P23396 (UniProtKB)
IPI
GO:0005634
P23396 (UniProtKB)
IDA
GO:0005634
P23396 (UniProtKB)
IDA
GO:0005634
P23396 (UniProtKB)
IDA
GO:0005634
P23396 (UniProtKB)
IDA
GO:0005634
P23396 (UniProtKB)
IDA
GO:0005634
P23396 (UniProtKB)
IDA
GO:0005634
P23396 (UniProtKB)
IDA
GO:0005634
P23396 (UniProtKB)
IMP
GO:0005634
P23396 (UniProtKB)
IMP
GO:0005654
P23396 (UniProtKB)
TAS
GO:0005730
P23396 (UniProtKB)
IDA
GO:0005737
P23396 (UniProtKB)
IDA
GO:0005737
P23396 (UniProtKB)
IDA
GO:0005737
P23396 (UniProtKB)
IDA
GO:0005737
P23396 (UniProtKB)
IDA
GO:0005737
P23396 (UniProtKB)
IMP
GO:0005743
P23396 (UniProtKB)
IDA
GO:0005759
P23396 (UniProtKB)
IDA
GO:0005829
P23396 (UniProtKB)
IDA
GO:0005829
P23396 (UniProtKB)
IDA
GO:0005829
P23396 (UniProtKB)
IDA
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005829
P23396 (UniProtKB)
TAS
GO:0005840
P23396 (UniProtKB)
IDA
GO:0005840
P23396 (UniProtKB)
IDA
GO:0005840
P23396 (UniProtKB)
IDA
GO:0005844
P23396 (UniProtKB)
IDA
GO:0005886
P23396 (UniProtKB)
IDA
GO:0005925
P23396 (UniProtKB)
IDA
GO:0006281
P23396 (UniProtKB)
IEA
GO:0006351
P23396 (UniProtKB)
IEA
GO:0006355
P23396 (UniProtKB)
IEA
GO:0006364
P23396 (UniProtKB)
TAS
GO:0006412
P23396 (UniProtKB)
NAS
GO:0006412
P23396 (UniProtKB)
IC
GO:0006413
P23396 (UniProtKB)
NAS
GO:0006413
P23396 (UniProtKB)
TAS
GO:0006614
P23396 (UniProtKB)
TAS
GO:0006974
P23396 (UniProtKB)
IEP
GO:0006979
P23396 (UniProtKB)
IDA
GO:0007059
P23396 (UniProtKB)
IMP
GO:0007067
P23396 (UniProtKB)
IEA
GO:0008017
P23396 (UniProtKB)
IDA
GO:0008134
P23396 (UniProtKB)
IPI
GO:0010628
P23396 (UniProtKB)
IMP
GO:0015631
P23396 (UniProtKB)
IDA
GO:0016020
P23396 (UniProtKB)
IDA
GO:0017148
P23396 (UniProtKB)
IDA
GO:0019083
P23396 (UniProtKB)
TAS
GO:0019899
P23396 (UniProtKB)
IPI
GO:0019899
P23396 (UniProtKB)
IPI
GO:0019899
P23396 (UniProtKB)
IPI
GO:0019900
P23396 (UniProtKB)
IPI
GO:0019900
P23396 (UniProtKB)
IPI
GO:0019901
P23396 (UniProtKB)
IPI
GO:0019901
P23396 (UniProtKB)
IPI
GO:0022627
P23396 (UniProtKB)
IDA
GO:0022627
P23396 (UniProtKB)
IDA
GO:0030529
P23396 (UniProtKB)
IDA
GO:0030544
P23396 (UniProtKB)
IDA
GO:0031116
P23396 (UniProtKB)
IMP
GO:0031397
P23396 (UniProtKB)
IDA
GO:0032079
P23396 (UniProtKB)
IDA
GO:0032183
P23396 (UniProtKB)
IPI
GO:0032357
P23396 (UniProtKB)
IDA
GO:0032358
P23396 (UniProtKB)
IDA
GO:0032587
P23396 (UniProtKB)
IDA
GO:0042769
P23396 (UniProtKB)
IMP
GO:0042769
P23396 (UniProtKB)
IDA
GO:0042981
P23396 (UniProtKB)
IMP
GO:0043507
P23396 (UniProtKB)
IMP
GO:0044390
P23396 (UniProtKB)
IPI
GO:0044822
P23396 (UniProtKB)
IDA
GO:0044822
P23396 (UniProtKB)
IDA
GO:0045738
P23396 (UniProtKB)
IMP
GO:0045739
P23396 (UniProtKB)
IDA
GO:0051018
P23396 (UniProtKB)
IPI
GO:0051225
P23396 (UniProtKB)
IMP
GO:0051301
P23396 (UniProtKB)
IEA
GO:0051536
P23396 (UniProtKB)
NAS
GO:0051879
P23396 (UniProtKB)
IDA
GO:0061481
P23396 (UniProtKB)
IDA
GO:0070062
P23396 (UniProtKB)
IDA
GO:0070062
P23396 (UniProtKB)
IDA
GO:0070181
P23396 (UniProtKB)
IDA
GO:0070301
P23396 (UniProtKB)
IDA
GO:0072686
P23396 (UniProtKB)
IDA
GO:0097100
P23396 (UniProtKB)
IDA
GO:1901224
P23396 (UniProtKB)
IDA
GO:1902231
P23396 (UniProtKB)
IMP
GO:1902546
P23396 (UniProtKB)
IDA
GO:1905053
P23396 (UniProtKB)
IDA
GO:2001235
P23396 (UniProtKB)
IDA
GO:2001272
P23396 (UniProtKB)
IMP
GO:0019104
P23396 (UniProtKB)
TAS
GO:0019104
P23396 (UniProtKB)
IDA
GO:0071159
P23396 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 RPS3基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
melanoma 0.12 1 0 CTD_human
Osteosarcoma 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Oedema auricular 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Transient ischemia 0.000271442 1 0 BeFree
Osteosarcoma of bone 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

The complete mitochondrial genome and phylogenetic analysis of Festuca pratensis.
Gong W, Tian C, Yang Y, Liu L, Feng Y, Wang F, Li Z, Wu Z Front Plant Sci IF: 5.9 None
Targeting SRPK3 Attenuates Cardiac Hypertrophy and Heart Failure by Improving Mitochondrial Bioenergetics through mRNA Splicing and Decay.
Zhan Y, Liang G, Wang J, Cen X, Zhang N, Zhao N, Xing Y, Li L, Yu T, Dong W, Deng W, Xie S Research (Wash D C) IF: 12.9 None
Ribosomal Proteins in Blood Exosomes as Markers of an Unfavorable Prognosis in Patients with Breast Cancer.
Shefer A, Babaylova E, Yanshole L, Grygoreva A, Svarovsky D, Graifer D, Malygin A, Chernyshovа A, Tamkovich S Asian Pac J Cancer Prev 2026-07-01
Heat shock protein family D member 1 (HSPD1) modulates ribosome-related pathways and protein synthesis in lung adenocarcinoma.
Somsuan K, Rongjumnong A, Chiangjong W, Ngoenkam J, Morchang A, Karamart P, Panachan J, Kaewboonruang P, Mongkolwat W, Chutipongtanate S, Pongcharoen S, Berghe WV, Aluksanasuwan S Mol Cell Biochem IF: 4.7 2026-08-10
LAPTM4B promotes gefitinib resistance and tumor stemness in non-small cell lung cancer by stabilizing RPS3 through inhibiting its ubiquitination.
Jiang Y, Xie WJ, Chen RW, Huang CL, You WQ, Chen H, You WW, Chen WX, Xu S, Xu JP Biochim Biophys Acta Mol Cell Res IF: 4.3 2026-10-00
EMB2217 Is a Mitochondrial PPR-SMR Protein Required for the Splicing of Multiple Group II Introns During Arabidopsis Development.
Marchetti F, Balestieri N, Becerra-Agudelo E, Valiñas M, Amigo N, Matan R, Mizrahi R, Takenaka M, Welchen E, Pagnussat GC, Ostersetzer-Biran O, Zabaleta E Physiol Plant IF: 4.0 None
Comparative plastome analyses of Lewinskya (Orthotrichaceae): insights into genome structure, molecular evolution, and phylogenetic relationships.
Han W, Zhang K, Zhao Y, Li Y, Luo H, Sun Z, Li Y, Liu X, Jia Y BMC Plant Biol IF: 5.6 2026-07-11
RPS5 modulates inflammatory response and angiogenesis in coronary heart disease through NF-κB signaling activation.
Han S, Li W, Huang Y, Xu Y, Song H, Qi W Mol Cell Biochem IF: 4.7 2026-08-00

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