TYRO3基因详情-基因数据库-基因云馆

TYRO3 (TYRO3 protein tyrosine kinase)

symbol:: TYRO3
locus group:: protein-coding gene
location:: 15q15.1
gene_family:: Receptor Tyrosine Kinases|Fibronectin type III domain containing|I-set domain containing|Immunoglobulin-like domain containing
alias symbol:: Dtk|Brt|Tif|Sky|Etk-2|Rek
alias name:: None
entrez id:: 7301
ensembl gene id:: ENSG00000092445
ucsc gene id:: uc001zof.3
refseq accession:: NM_001330264
hgnc_id:: HGNC:12446
approved reserved:: 1992-10-02

15q15.1

TYRO3是一种受体酪氨酸激酶（RTK），属于TAM受体家族（包括TYRO3、AXL和MER），主要参与细胞信号传导，调控免疫调节、细胞存活、增殖和凋亡等过程。其表达产物是一种跨膜蛋白，通过结合配体（如GAS6和PROS1）激活下游信号通路（如PI3K-AKT和MAPK），影响细胞功能。TYRO3在神经系统、免疫系统和生殖系统中高表达，尤其在神经元、小胶质细胞和精子细胞中发挥重要作用，促进神经保护、突触可塑性和免疫耐受。基因突变可能导致功能丧失或异常激活，与癌症（如白血病、黑色素瘤）、自身免疫疾病（如系统性红斑狼疮）和神经退行性疾病（如阿尔茨海默病）相关。过表达TYRO3可能增强细胞存活和迁移，促进肿瘤进展和转移，同时抑制抗肿瘤免疫反应；而表达降低可能导致神经保护功能减弱或免疫失调。TAM家族的共性是依赖磷脂酰丝氨酸（PS）结合的配体激活，参与调控炎症、吞噬作用和稳态维持。专业术语解释：受体酪氨酸激酶（RTK）是细胞表面受体，通过磷酸化传递信号；PI3K-AKT和MAPK是促进细胞生长和存活的信号通路；GAS6和PROS1是TYRO3的配体蛋白；小胶质细胞是中枢神经系统的主要免疫细胞。目前中文术语"TAM受体家族"（原文TAM receptor family）和"GAS6"（生长停滞特异性蛋白6）等名称已广泛使用。

中文English

的基因是与染色体15的加工型假远侧编码的蛋白质是由生长特异性阻滞基因6和S蛋白的基因的产物活化，并参与3-构件跨膜受体激酶受体家族的一部分在控制细胞存活和增殖，精子发生，免疫调节和吞噬。所编码的蛋白质也被确定为埃博拉和马尔堡病毒进入细胞因子。 [由RefSeq的，2010年5月提供]

OMIM数据库中对TYRO3基因的介绍 Wikipedia数据库中对TYRO3基因的介绍

TYRO3基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA
41AGLKLMGAPV KLTVSQGQPV KLNCSVEGME EPDIQWVKDG
81
AVVQNLDQL YIPVSEQHWI GFLSLKSVER SDAGRYWCQV
121EDGGETEISQ PVWLTVEGVP FFTVEPKDLA VPPNAPFQLS
161C
EAVGPPEP VTIVWWRGTT KIGGPAPSPS VLNVTGVTQS
201TMFSCEAHNL KGLASSRTAT VHLQALPAAP FNITVTKLSS
241SN
ASVAWMP GADGRALLQS CTVQVTQAPG GWEVLAVVVP
281VPPFTCLLRD LVPATNYSLR VRCANALGPS PYADWVPFQT
321KGL
APASAP QNLHAIRTDS GLILEWEEVI PEAPLEGPLG
361PYKLSWVQDN GTQDELTVEG TRANLTGWDP QKDLIVRVCV
401SNAV
GCGPW SQPLVVSSHD RAGQQGPPHS RTSWVPVVLG
441VLTALVTAAA LALILLRKRR KETRFGQAFD SVMARGEPAV
481HFRAA
RSFN RERPERIEAT LDSLGISDEL KEKLEDVLIP
521EQQFTLGRML GKGEFGSVRE AQLKQEDGSF VKVAVKMLKA
561DIIASS
DIE EFLREAACMK EFDHPHVAKL VGVSLRSRAK
601GRLPIPMVIL PFMKHGDLHA FLLASRIGEN PFNLPLQTLI
641RFMVDIA
CG MEYLSSRNFI HRDLAARNCM LAEDMTVCVA
681DFGLSRKIYS GDYYRQGCAS KLPVKWLALE SLADNLYTVQ
721SDVWAFGV
T MWEIMTRGQT PYAGIENAEI YNYLIGGNRL
761KQPPECMEDV YDLMYQCWSA DPKQRPSFTC LRMELENILG
801QLSVLSASQ
 DPLYINIERA EEPTAGGSLE LPGRDQPYSG
841AGDGSGMGAV GGTPSDCRYI LTPGGLAEQP GQAEHQPESP
881LNETQRLLLL 
QQGLLPHSS C

结构预测来自 AlphaFold DB（UniProt: Q06418），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

TYRO3基因的碱基突变：仅显示部分snp

rs2681 rs12259 rs735149 rs1023193 rs1023194 rs1042057 rs1042061 rs1200338 rs1200339 rs1200341 rs1200342 rs1200343 rs2246444 rs2277536 rs2277537 rs2289742 rs2289743

TYRO3基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TTCAGACCAAGGGTCTAGC

58

AGATGAGGCCTGAATCTGTG

59

ACGCTGAGATTTACAACTACCT

60

TGAGATCATACACGTCCTCC

59

TGAAGATGCTGAAAGCTGAC

59

GGTCAAACTCCTTCATGCA

58

GAGCTTTACTTGTCTGCGA

58

AGATAGCACAGACAGCTGG

59

GGTCTGAAGCTCATGGGAG

60

TCCAAGTTCTGGACCACAG

59

GTTCAAGACAATGGAACCCA

58

CACAGGTACCCAGGATGTG

60

CGCTGAGATTTACAACTACCT

58

GGGAGTGTAAGAACGTCCT

59

ACGCTGAGATTTACAACTACCT

60

TGAGATCATACACGTCCTCC

59

TGAAGATGCTGAAAGCTGAC

58

GGTCAAACTCCTTCATGCA

58

GACATCATTGCCTCAAGCG

60

ATGAAGGGCAAGATGACCA

59

尚未收录相关数据

TYRO3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

TYRO3基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004713

H0YNK6 (UniProtKB)

IEA

GO:0005524

H0YNK6 (UniProtKB)

IEA

GO:0016021

H0YNK6 (UniProtKB)

IEA

GO:0018108

H0YNK6 (UniProtKB)

IEA

GO:0004713

H3BPR7 (UniProtKB)

IEA

GO:0005524

H3BPR7 (UniProtKB)

IEA

GO:0018108

H3BPR7 (UniProtKB)

IEA

GO:0001618

Q06418 (UniProtKB)

IEA

GO:0001779

Q06418 (UniProtKB)

IEA

GO:0004713

Q06418 (UniProtKB)

IDA

GO:0004714

Q06418 (UniProtKB)

NAS

GO:0004716

Q06418 (UniProtKB)

NAS

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005515

Q06418 (UniProtKB)

IPI

GO:0005524

Q06418 (UniProtKB)

IEA

GO:0005634

Q06418 (UniProtKB)

ISS

GO:0005635

Q06418 (UniProtKB)

ISS

GO:0005789

Q06418 (UniProtKB)

ISS

GO:0005887

Q06418 (UniProtKB)

NAS

GO:0007155

Q06418 (UniProtKB)

NAS

GO:0007165

Q06418 (UniProtKB)

NAS

GO:0007283

Q06418 (UniProtKB)

ISS

GO:0014065

Q06418 (UniProtKB)

NAS

GO:0018108

Q06418 (UniProtKB)

IEA

GO:0018108

Q06418 (UniProtKB)

IEA

GO:0021885

Q06418 (UniProtKB)

ISS

GO:0023014

Q06418 (UniProtKB)

IEA

GO:0030168

Q06418 (UniProtKB)

ISS

GO:0032940

Q06418 (UniProtKB)

ISS

GO:0034122

Q06418 (UniProtKB)

ISS

GO:0034446

Q06418 (UniProtKB)

ISS

GO:0042698

Q06418 (UniProtKB)

ISS

GO:0043277

Q06418 (UniProtKB)

ISS

GO:0043491

Q06418 (UniProtKB)

ISS

GO:0043524

Q06418 (UniProtKB)

ISS

GO:0043548

Q06418 (UniProtKB)

IPI

GO:0045824

Q06418 (UniProtKB)

ISS

GO:0046718

Q06418 (UniProtKB)

IEA

GO:0046777

Q06418 (UniProtKB)

IDA

GO:0046777

Q06418 (UniProtKB)

IDA

GO:0046982

Q06418 (UniProtKB)

IEA

GO:0050728

Q06418 (UniProtKB)

ISS

GO:0051250

Q06418 (UniProtKB)

IEA

GO:0060068

Q06418 (UniProtKB)

IEA

GO:0070050

Q06418 (UniProtKB)

ISS

GO:0070527

Q06418 (UniProtKB)

ISS

可能调控 TYRO3基因的相关microRNA：

String

BioGrid

IntAct

mentha

MINT

加载中…

关联基因	作用方式	资源库来源/分值

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Thrombosis	0.12	1	0	CTD_human
Atherosclerosis	0.002367032	1	0	GAD
Congenital chromosomal disease	0.001628651	6	0	BeFree
Acute lymphocytic leukemia	0.000542884	2	0	BeFree
Leukemia, Myelocytic, Acute	0.000542884	2	0	BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma	0.000542884	2	0	BeFree
Carcinogenesis	0.000542884	2	0	BeFree
Neoplasm Metastasis	0.000542884	2	0	BeFree
Lung Neoplasms	0.000542884	2	0	BeFree
leukemia	0.000542884	2	0	BeFree

Evaluation of Plasma-Derived hsa_circ_003077 for Non-Invasive Diagnosis of Alzheimer's Disease.

Çelik H, Çelik O, Aydın Ş, Küçükler S, Çomaklı S, Akay R, Gönüllü S, Yıldız MO, Alım B, Özdemir S Biomolecules 2026-02-26

Integrative computational analysis of Marburg virus protein mutations: structural and functional implications of Glycoprotein variants and natural inhibitor screening.

Aktaş E, Öztürk S, Tarhan B J Biomol Struct Dyn IF: 2.5 2026-03-28

Targeting HIF-1α rescues microglial efferocytosis via the SLC7A11-TAM pathway to ameliorate Sepsis-associated encephalopathy.

Wang S, Chen Y, Sun Z, Zeng Y, Wang G, Lin Q, Chen C, He H Int Immunopharmacol IF: 5.6 2026-06-15

The efferocytosis-related genes of SLC26A6, TYRO3, and PDK4 have been identified as predictors of prognosis in hepatocellular carcinoma and are associated with the immune status.

Yang JJ, Ouyang Q, Zeng XX, Cen WJ, Deng L, Song GP, Wang F, Sun LY Int J Med Sci IF: 3.7 None

Preclinical evaluation of CPL423: a novel potent small-molecule inhibitor of TAM family and FLT3 kinase for cancer therapy.

Mikołajczyk A, Popiel D, Jastrzębska K, Wiernicki B, Mituła F, Janusz A, Dominowski J, Górka M, Kornatowski T, Hucz-Kalitowska J, Teska-Kamińska M, Smuga D, Delis M, Kamecki K, Maliszewski P, Yamani A, Dubiel K, Pieczykolan J, Wieczorek M Front Pharmacol IF: 4.400 None

GAS6 potentiates tumor progression through modulating suppressive microenvironments.

Lu S, Liu H, Zhang F, Wang J, Huang Y, Chen J, Xu S, Cui L, Li T Am J Cancer Res IF: 3.1 None

tRF-GluCTC promotes VSMC apoptosis and oxidative stress by targeting TYRO3 in intracranial aneurysm.

Wang C, Yu B, Cui Z, Chen B, Zhang H, Li S, Guo P, Yu T, Feng Y Atherosclerosis IF: 7.1 2026-04-00

First-Trimester Maternal Serum Growth Arrest-Specific Protein 6 (Gas6) Levels for the Prediction of Preeclampsia.

Yılmaz Z, Yurtcu N, Karademir D, Calıskan CS, Celik S J Clin Med 2026-07-17

Differential Susceptibility to OsHV-1 in Two Geographic Populations of Ark Clam (Scapharca broughtonii) Based on Transcriptomic and Proteomic Analysis.

Liu Q, Lian S, Qiu Z, Hou Y, Zhou Y, Li C, Liu H, Xin L Microorganisms 2026-06-30

Receptor-Ligand Biomarker Profile in Ankylosing Spondylitis: Associations Between AXL/MERTK Expression, Circulating GAS6 and Protein S Levels, and Disease Activity.

Dogan SC, Zontul C, Atas M, Ozmen E, Kaya GC, Tas A, Karadag A Life (Basel) 2026-06-26

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TYRO3 (TYRO3 protein tyrosine kinase)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

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