Home LiteratureArticle Details
PMID: 10024242 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Nonmethylated transposable elements and methylated genes in a chordate genome.

Science (New York, N.Y.) ·Vol. 283 ·No. 5405 ·1999-02-19 ·Pages 1164-7

Simmen MW, Leitgeb S, Charlton J, Jones SJ, Harris BR, Clark VH, Bird A

Abstract

The genome of the invertebrate chordate Ciona intestinalis was found to be a stable mosaic of methylated and nonmethylated domains. Multiple copies of an apparently active long terminal repeat retrotransposon and a long interspersed element are nonmethylated and a large fraction of abundant short interspersed elements are also methylation free. Genes, by contrast, are predominantly methylated. These data are incompatible with the genome defense model, which proposes that DNA methylation in animals is primarily targeted to endogenous transposable elements. Cytosine methylation in this urochordate may be preferentially directed to genes.

MeSH Terms
Animals Ciona intestinalis/genetics Cosmids Cytosine/metabolism DNA Methylation DNA Transposable Elements Dinucleoside Phosphates/metabolism Genome Long Interspersed Nucleotide Elements Repetitive Sequences, Nucleic Acid Retroelements Short Interspersed Nucleotide Elements Terminal Repeat Sequences
Chemicals
DNA Transposable Elements Dinucleoside Phosphates Retroelements cytidylyl-3'-5'-guanosine Cytosine
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Simmen M W
Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, Edinburgh EH9 3JR, UK.
Leitgeb S
Charlton J
Jones S J
Harris B R
Clark V H
Bird A
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.283.5405.1164
Published
1999-02-19
Pages
1164-7
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
Wellcome Trust · United Kingdom
Databases
GENBANK
AJ226133, AJ226134, AJ226135, AJ226136, AJ226137, AJ226138, AJ226139, AJ226140, AJ226141, AJ226142, AJ226143, AJ226144, AJ226145, AJ226146, AJ226147, AJ226148, AJ226149, AJ226150, AJ226151, AJ226152, AJ226153, AJ226154, AJ226155, AJ226156, AJ226157, AJ226159, AJ226160, AJ226161, AJ226162, AJ226163
External Links
PubMed source DOI: 10.1126/science.283.5405.1164 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2