Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.
The ability of cytotoxic T lymphocytes (CTL) induced in vitro to trinitrophenyl (TNP)-modified syngeneic cells to cross-reactively lyse a TNP allogeneic spleen target varies among inbred mouse strains. The cross-reactive CTL phenotype was found to be histocompatibility 2 (H-2) linked and to be dominant in F1 hybrid mice. All strains investigated demonstrated cross-reactivity except for some strains bearing portions of the H-2k haplotype. The gene(s) controlling this response maps to the K and/or I-A region of the H-2 complex. We have termed the immune response (Ir) gene responsible for controlling the specificity of CTL induced to TNP-modified syngeneic cells Ir-X-TNP.
14 references, click to expand
-
Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier.Nature. 1975 Jul 31;256(5516):419-21 PMID: 1079924
-
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.Proc Natl Acad Sci U S A. 1976 Feb;73(2):625-9 PMID: 1082140
-
Participation of the H-2 antigens of tumor cells in their lysis by syngeneic T cells.J Exp Med. 1976 Mar 1;143(3):601-14 PMID: 1082492
-
An estimation of the frequency of precursor cells which generate cytotoxic lymphocytes.J Exp Med. 1976 Jun 1;143(6):1562-7 PMID: 1083894
-
Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.J Exp Med. 1976 Dec 1;144(6):1609-20 PMID: 1087327
-
Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.J Exp Med. 1976 Dec 1;144(6):1701-6 PMID: 1087329
-
Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.J Exp Med. 1977 Mar 1;145(3):508-22 PMID: 233899
-
Quantitative studies of the activation of cytotoxic lymphocyte precursor cells.Immunol Rev. 1977;35:38-58 PMID: 330390
-
Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.Adv Immunol. 1974;18:67-132 PMID: 4151339
-
Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.Eur J Immunol. 1974 Aug;4(8):527-33 PMID: 4547153
-
Role of the murine major histocompatibility complex in the specificity of in vitro T-cell-mediated lympholysis against chemically-modified autologous lymphocytes.Transplant Rev. 1976;29:222-46 PMID: 58458
-
Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.Transplant Rev. 1976;29:89-124 PMID: 58463
-
Genetic control of the immune response to Thy-1 antigens.Immunol Rev. 1978;38:120-62 PMID: 75164
-
Inhibition of T-lymphocyte-mediated tumor-specific lysis by alloantisera directed against the H-2 serological specificities of the tumor.J Exp Med. 1975 Oct 1;142(4):1023-8 PMID: 809532
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
