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PMID: 10072356 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The INK4A/ARF locus and its two gene products.

Current opinion in genetics & development ·Vol. 9 ·No. 1 ·1999-02-00 ·Pages 22-30

Sharpless NE, DePinho RA

Abstract

The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.

MeSH Terms

Amino Acid Sequence Cyclin-Dependent Kinase Inhibitor p16/genetics Genes, Tumor Suppressor/genetics Genes, p16/genetics Humans Molecular Sequence Data Mutation Neoplasms/genetics Proteins/genetics Sequence Homology, Amino Acid Tumor Suppressor Protein p14ARF

Chemicals

Cyclin-Dependent Kinase Inhibitor p16 Proteins Tumor Suppressor Protein p14ARF

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sharpless N E

Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA. [email protected]

DePinho R A

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(99)80004-5

[email protected]

Published

1999-02-00

Pages

22-30

Language

English

Region

England

NLM ID

9111375

Subset

Grants

NEI NIH HHS · R01 EY11267 · United States

NICHD NIH HHS · R01 HD28317 · United States

External Links

PubMed source DOI: 10.1016/s0959-437x(99)80004-5 View journal details

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The INK4A/ARF locus and its two gene products.

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