Binding of phytohaemagglutinin to serum substances and inhibition of lymphocyte transformation in Hodgkin's disease.

Clinical and experimental immunology ·Vol. 26 ·No. 3 ·1976-12-00 ·Pages 520-7

Amlot PL, Unger A

Abstract

Serum from eleven of fifty-four patients with Hodgkin's disease inhibited phytohaemagglutinin (PHA) stimulation of both autologous and homologous lymphocytes. The inhibitory effect resided in the macromolecular fraction of these sera. PHA was shown to bind to serum substances in inhibitory sera and the degree of PHA binding in the macromolecular fraction correlated directly with the extent of inhibition.

MeSH Terms

Blood Cell Survival Female Hodgkin Disease/immunology Humans Lectins Lymphocyte Activation Male Protein Binding

Chemicals

Lectins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Amlot P L

Unger A

References (16)

16 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1976-12-00

Pages

520-7

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1540991

Subset

External Links

PubMed source PMC Full Text View journal details

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Binding of phytohaemagglutinin to serum substances and inhibition of lymphocyte transformation in Hodgkin's disease.

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