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PMID: 10179 Published · ppublish English Journal Article

Similarities between sodium channels in excitable membranes and in epithelia.

Experientia ·Vol. 32 ·No. 10 ·1976-10-15 ·Pages 1321-3

Cuthbert AW

Abstract

The inhibitory effects of the pyrazine derivative, amiloride, on sodium transport in an amphibian epithelium has been studied as a function of pH. It is concluded that the charged (guanidinium) group interacts with a negatively charged acid grouping in the membrane. Similarities between sodium channels in excitable membranes and epithelia are highlighted.

MeSH Terms
Amiloride/pharmacology Animals Biological Evolution Biological Transport/drug effects Cell Membrane/metabolism Hydrogen-Ion Concentration Isoelectric Point Rana temporaria Skin/metabolism Sodium/metabolism Structure-Activity Relationship
Chemicals
Amiloride Sodium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Cuthbert A W
References (14)
14 references, click to expand
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01953117
Published
1976-10-15
Pages
1321-3
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01953117
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