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PMID: 10203785 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

PTEN: a tumour suppressor that functions as a phospholipid phosphatase.

Trends in cell biology ·Vol. 9 ·No. 4 ·1999-04-00 ·Pages 125-8

Maehama T, Dixon JE

Abstract

The tumour suppressor PTEN has been implicated in a large number of human tumours and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, including phosphatidylinositol (3,4,5)-trisphosphate, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signalling. This article discusses the function of PTEN and how this could be linked to its activity as a tumour suppressor.

MeSH Terms

Amino Acid Sequence Animals DNA Mutational Analysis DNA, Neoplasm/genetics Evolution, Molecular Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Genes, Lethal Genes, Tumor Suppressor Helminth Proteins/genetics Humans Inositol Phosphates/metabolism Invertebrates/genetics Mammals/genetics Mice Mice, Knockout Molecular Sequence Data Neoplasms/enzymology,genetics PTEN Phosphohydrolase Phosphatidylinositols/metabolism Phospholipids/metabolism Phosphoric Monoester Hydrolases/physiology Phosphorylation Saccharomyces cerevisiae/genetics Sequence Alignment Sequence Homology, Amino Acid Species Specificity Substrate Specificity Tumor Suppressor Proteins

Chemicals

DNA, Neoplasm Helminth Proteins Inositol Phosphates Phosphatidylinositols Phospholipids Tumor Suppressor Proteins inositol 3,4,5-trisphosphate Phosphoric Monoester Hydrolases PTEN Phosphohydrolase PTEN protein, human

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Maehama T

Dept of Biological Chemistry, University of Michigan, USA.

Dixon J E

Article Info

Journal

Trends in cell biology

Abbr.

Trends Cell Biol

ISSN

0962-8924

DOI

10.1016/s0962-8924(99)01519-6

Published

1999-04-00

Pages

125-8

Language

English

Region

England

NLM ID

9200566

Subset

Grants

NIDDK NIH HHS · NIDDK18024 · United States

NIDDK NIH HHS · NIDDK18849 · United States

External Links

PubMed source DOI: 10.1016/s0962-8924(99)01519-6 View journal details

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase.

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