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PMID: 103002 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity.

Nature ·Vol. 276 ·No. 5690 ·1978-00-00 ·Pages 780-4

Valbuena O, Marcu KB, Weigert M, Perry RP

Abstract

The number of germline genes specifying the variable sequences of the Vkappa21 group of light chains was determined by saturation hybridisation analysis to be four to six. This gene multiplicity is considerably less than the total variability in the group, indicating that kappa-chain diversity is generated by somatic mutations in both framework and complementarity-determining (hypervariable) regions.

MeSH Terms

Alleles Animals Antibody Specificity Base Sequence Binding Sites, Antibody/genetics Genes Immunoglobulin Light Chains/genetics Immunoglobulin Variable Region/genetics Immunoglobulin kappa-Chains/genetics Mice Mutation Myeloma Proteins/genetics Nucleic Acid Hybridization RNA, Messenger/genetics

Chemicals

Immunoglobulin Light Chains Immunoglobulin Variable Region Immunoglobulin kappa-Chains Myeloma Proteins RNA, Messenger

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Valbuena O

Marcu K B

Weigert M

Perry R P

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/276780a0

Published

1978-00-00

Pages

780-4

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/276780a0 View journal details

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Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity.

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