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PMID: 103100 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Immunization against malaria with antigen from Plasmodium falciparum cultivated in vitro.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 11 ·1978-11-00 ·Pages 5665-8

Reese RT, Trager W, Jensen JB, Miller DA, Tantravahi R

Abstract

Aotus monkeys, which are generally killed when infected with the human malaria parasite Plasmodium falciparum, have been identified and grouped by karyotype. These animals were immunized with parasite material obtained from P. falciparum cultivated in vitro which had been maintained in culture for over a year. When sufficient amounts of this antigenic material were used with a synthetic muramyl dipeptide (MDP), protective immunity was induced without presenting the antigen in complete Freund's adjuvant.

MeSH Terms
Animals Antigens Erythrocytes/immunology Haplorhini Immunity Immunization Malaria/immunology Plasmodium falciparum/immunology
Chemicals
Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Reese R T
Trager W
Jensen J B
Miller D A
Tantravahi R
References (20)
20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.11.5665
Published
1978-11-00
Pages
5665-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC393028
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.11.5665 PMC Full Text View journal details
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