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PMID: 103580 Published · ppublish English Journal Article

Insulin counteraction of alpha-adrenergic effects on liver glycogen metabolism.

Biochimica et biophysica acta ·Vol. 543 ·No. 2 ·1978-10-03 ·Pages 269-72

Massagué J, Guinovart JJ

Abstract

Insulin counteracted the effects of a pure alpha-adrenergic agonist, phenylephrine, on hepatocyte glycogen synthase and phosphorylase. These results argue against current concepts of insulin increasing cytoplasmic Ca2+ concentration.

MeSH Terms
Animals Glycogen Synthase/metabolism In Vitro Techniques Insulin/pharmacology Liver/drug effects,metabolism Liver Glycogen/metabolism Male Phenylephrine/antagonists & inhibitors Phosphorylases/metabolism Rats
Chemicals
Insulin Liver Glycogen Phenylephrine Phosphorylases Glycogen Synthase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Massagué J
Guinovart J J
Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/0304-4165(78)90073-9
Published
1978-10-03
Pages
269-72
Language
English
Region
Netherlands
NLM ID
0217513
Subset
IM
External Links
PubMed source DOI: 10.1016/0304-4165(78)90073-9
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