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PMID: 10362784 Published · ppublish English Comment Journal Article

Genetic instability and the mutator phenotype. Studies in ulcerative colitis.

The American journal of pathology ·Vol. 154 ·No. 6 ·1999-06-00 ·Pages 1621-6

Loeb KR, Loeb LA

Abstract

暂无摘要

MeSH Terms
Chromosome Aberrations/genetics Colitis, Ulcerative/complications,genetics Colonic Neoplasms/complications,genetics Humans Microsatellite Repeats/genetics Mutagenesis Phenotype
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Loeb K R
Loeb L A
References (42)
42 references, click to expand
  1. Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.
    Int J Mol Med. 1998 Aug;2(2):221-224 PMID: 9855692
  2. Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors.
    Genes Chromosomes Cancer. 1996 Apr;15(4):234-45 PMID: 8703849
  3. Cell cycle checkpoints: preventing an identity crisis.
    Science. 1996 Dec 6;274(5293):1664-72 PMID: 8939848
  4. The spontaneous azaguanine-resistant mutants of diploid human fibroblasts.
    Humangenetik. 1972;16(1):87-110 PMID: 4647448
  5. Atypical mitoses in colectomy specimens from patients with long standing ulcerative colitis.
    Anticancer Res. 1997 Jul-Aug;17(4A):2721-6 PMID: 9252704
  6. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
    Science. 1997 Feb 14;275(5302):967-9 PMID: 9020077
  7. Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia.
    Am J Pathol. 1999 Jun;154(6):1825-30 PMID: 10362807
  8. Genetic analysis of benign, low-grade, and high-grade ovarian tumors.
    Cancer Res. 1995 Dec 15;55(24):6172-80 PMID: 8521410
  9. The spindle checkpoint.
    Trends Genet. 1998 Jan;14(1):1-4 PMID: 9448456
  10. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair.
    Nature. 1993 Sep 16;365(6443):274-6 PMID: 8371783
  11. Comparative genomic in situ hybridization of colon carcinomas with replication error.
    Cancer Res. 1995 Dec 15;55(24):6002-5 PMID: 8521381
  12. DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis.
    Gastroenterology. 1992 Nov;103(5):1611-20 PMID: 1426881
  13. Cell cycle control and cancer.
    Science. 1994 Dec 16;266(5192):1821-8 PMID: 7997877
  14. Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9441-5 PMID: 2687881
  15. Mismatch repair, genetic stability and tumour avoidance.
    Philos Trans R Soc Lond B Biol Sci. 1995 Jan 30;347(1319):89-95 PMID: 7746860
  16. Clues to the pathogenesis of familial colorectal cancer.
    Science. 1993 May 7;260(5109):812-6 PMID: 8484121
  17. Genetic instabilities in human cancers.
    Nature. 1998 Dec 17;396(6712):643-9 PMID: 9872311
  18. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
    Cell. 1993 Dec 3;75(5):1027-38 PMID: 8252616
  19. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.
    Cell. 1991 Aug 9;66(3):507-17 PMID: 1651171
  20. Mitotic forces control a cell-cycle checkpoint.
    Nature. 1995 Feb 16;373(6515):630-2 PMID: 7854422
  21. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis.
    Nature. 1993 Jun 10;363(6429):558-61 PMID: 8505985
  22. Hypermutability and mismatch repair deficiency in RER+ tumor cells.
    Cell. 1993 Dec 17;75(6):1227-36 PMID: 8261516
  23. Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog.
    Nat Med. 1999 Jan;5(1):11-2 PMID: 9883827
  24. Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis.
    Cancer Res. 1996 Mar 15;56(6):1237-40 PMID: 8640805
  25. Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery.
    Annu Rev Genet. 1998;32:307-37 PMID: 9928483
  26. Mutation of a mutL homolog in hereditary colon cancer.
    Science. 1994 Mar 18;263(5153):1625-9 PMID: 8128251
  27. Genetic instability in colorectal cancers.
    Nature. 1997 Apr 10;386(6625):623-7 PMID: 9121588
  28. Predominance of normal karyotype in colorectal tumors from hereditary non-polyposis colorectal cancer patients.
    Genes Chromosomes Cancer. 1995 Nov;14(3):223-6 PMID: 8589041
  29. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
    Science. 1995 Jun 2;268(5215):1336-8 PMID: 7761852
  30. Mutator phenotype may be required for multistage carcinogenesis.
    Cancer Res. 1991 Jun 15;51(12):3075-9 PMID: 2039987
  31. Mutations of mitotic checkpoint genes in human cancers.
    Nature. 1998 Mar 19;392(6673):300-3 PMID: 9521327
  32. Errors in DNA replication as a basis of malignant changes.
    Cancer Res. 1974 Sep;34(9):2311-21 PMID: 4136142
  33. Microsatellite instability: marker of a mutator phenotype in cancer.
    Cancer Res. 1994 Oct 1;54(19):5059-63 PMID: 7923117
  34. Ulcerative colitis and colorectal cancer. A population-based study.
    N Engl J Med. 1990 Nov 1;323(18):1228-33 PMID: 2215606
  35. When checkpoints fail.
    Cell. 1997 Feb 7;88(3):315-21 PMID: 9039258
  36. The mutation rate and cancer.
    Genetics. 1998 Apr;148(4):1483-90 PMID: 9560368
  37. Genetic alterations during colorectal-tumor development.
    N Engl J Med. 1988 Sep 1;319(9):525-32 PMID: 2841597
  38. Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: effect of folate supplementation.
    Am J Gastroenterol. 1998 Nov;93(11):2060-4 PMID: 9820373
  39. Factors affecting fidelity of DNA synthesis during PCR amplification of d(C-A)n.d(G-T)n microsatellite repeats.
    Nucleic Acids Res. 1996 Jun 15;24(12):2429-34 PMID: 8710517
  40. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
    Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5 PMID: 9618505
  41. The clonal evolution of tumor cell populations.
    Science. 1976 Oct 1;194(4260):23-8 PMID: 959840
  42. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle.
    J Cell Biol. 1994 Dec;127(5):1301-10 PMID: 7962091
Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
DOI
10.1016/S0002-9440(10)65415-6
Published
1999-06-00
Pages
1621-6
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1866616
Subset
IM
Corrections
CommentOn
PMID: 10362807
External Links
PubMed source DOI: 10.1016/S0002-9440(10)65415-6 PMC Full Text View journal details
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