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PMID: 10364153 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

p53-mediated apoptosis is attenuated in Werner syndrome cells.

Genes & development ·Vol. 13 ·No. 11 ·1999-06-01 ·Pages 1355-60

Spillare EA, Robles AI, Wang XW, Shen JC, Yu CE, Schellenberg GD, Harris CC

Abstract

The WRN DNA helicase is a member of the DExH-containing DNA helicase superfamily that includes XPB, XPD, and BLM. Mutations in WRN are found in patients with the premature aging and cancer susceptibility syndrome known as Werner syndrome (WS). p53 binds to the WRN protein in vivo and in vitro through its carboxyl terminus. WS fibroblasts have an attenuated p53- mediated apoptotic response, and this deficiency can be rescued by expression of wild-type WRN. These data support the hypothesis that p53 can induce apoptosis through the modulation of specific DExH-containing DNA helicases and may have implications for the cancer predisposition observed in WS patients.

MeSH Terms
Animals Apoptosis DNA Helicases/genetics,metabolism Exodeoxyribonucleases Fibroblasts/cytology,metabolism Humans Mice RecQ Helicases Tumor Cells, Cultured Tumor Suppressor Protein p53/genetics,metabolism Werner Syndrome/pathology Werner Syndrome Helicase
Chemicals
Tumor Suppressor Protein p53 Exodeoxyribonucleases DNA Helicases RecQ Helicases WRN protein, human Werner Syndrome Helicase
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Spillare E A
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.
Robles A I
Wang X W
Shen J C
Yu C E
Schellenberg G D
Harris C C
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.13.11.1355
Published
1999-06-01
Pages
1355-60
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC316776
Subset
IM
Grants
NIA NIH HHS · AG05427 · United States
NIA NIH HHS · AG12019 · United States
External Links
PubMed source DOI: 10.1101/gad.13.11.1355 PMC Full Text View journal details
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