Home LiteratureArticle Details
PMID: 10375554 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Signal transduction from the B cell antigen-receptor.

Current opinion in immunology ·Vol. 11 ·No. 3 ·1999-06-00 ·Pages 256-64

Campbell KS

Abstract

Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways controlling the mitogen-activated protein kinases (ERK, JNK and p38).

MeSH Terms
Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals B-Lymphocytes/immunology,metabolism Calcium-Calmodulin-Dependent Protein Kinases/metabolism Carrier Proteins/metabolism GTP-Binding Proteins/metabolism GTPase-Activating Proteins Humans Models, Biological Phosphatidylinositol 3-Kinases/metabolism Phosphoproteins/metabolism Receptors, Antigen, B-Cell/chemistry,metabolism Signal Transduction/immunology,physiology ras Proteins/metabolism
Chemicals
Adaptor Proteins, Signal Transducing B cell linker protein Carrier Proteins GTPase-Activating Proteins Phosphoproteins Receptors, Antigen, B-Cell rho GTPase-activating protein Phosphatidylinositol 3-Kinases Calcium-Calmodulin-Dependent Protein Kinases GTP-Binding Proteins ras Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Campbell K S
Fox Chase Cancer Center, Institute for Cancer Research, Division of Basic Science, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. [email protected].
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/s0952-7915(99)80042-9
Email
[email protected]
Published
1999-06-00
Pages
256-64
Language
English
Region
England
NLM ID
8900118
Subset
IM
Grants
NCI NIH HHS · CA06927 · United States
External Links
PubMed source DOI: 10.1016/s0952-7915(99)80042-9 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2