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PMID: 10393694 Published · ppublish English Journal Article

Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis.

The Journal of clinical investigation ·Vol. 104 ·No. 1 ·1999-07-00 ·Pages 13-9

Kuwano K, Hagimoto N, Kawasaki M, Yatomi T, Nakamura N, Nagata S, Suda T, Kunitake R, Maeyama T, Miyazaki H, Hara N

Abstract

The Fas ligand is predominantly expressed in activated T lymphocytes and is one of the major effector molecules of cytotoxic T lymphocytes and natural killer cells. Previously, we found excessive apoptosis of epithelial cells and infiltrating lymphocytes expressing Fas ligand mRNA in the lung tissue of bleomycin-induced pulmonary fibrosis in mice. Here we demonstrated that the administration of a soluble form of Fas antigen or anti-Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant against the induction of pneumopathy. These results suggest that the Fas-Fas ligand pathway plays an essential role in the development of pulmonary fibrosis and that preventing this pathway could have therapeutic value in lung injury and fibrosis.

MeSH Terms
Animals Apoptosis Bleomycin/toxicity Fas Ligand Protein Humans Hydroxyproline/analysis Immunoglobulin Fc Fragments/genetics,immunology In Situ Nick-End Labeling Killer Cells, Natural/immunology Lung/chemistry,pathology Membrane Glycoproteins/deficiency,genetics,physiology Mice Mice, Inbred C3H Mice, Inbred ICR Mice, Inbred MRL lpr Mice, Mutant Strains Phagocytosis Pulmonary Fibrosis/immunology,pathology,prevention & control Recombinant Fusion Proteins/physiology T-Lymphocytes, Cytotoxic/immunology fas Receptor/genetics,physiology
Chemicals
FASLG protein, human Fas Ligand Protein Fasl protein, mouse Immunoglobulin Fc Fragments Membrane Glycoproteins Recombinant Fusion Proteins fas Receptor Bleomycin Hydroxyproline
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Kuwano K
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan. [email protected]
Hagimoto N
Kawasaki M
Yatomi T
Nakamura N
Nagata S
Suda T
Kunitake R
Maeyama T
Miyazaki H
Hara N
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI5628
Email
[email protected]
Published
1999-07-00
Pages
13-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC408400
Subset
IM
Corrections
CommentIn
PMID: 10393691
External Links
PubMed source DOI: 10.1172/JCI5628 PMC Full Text View journal details
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