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PMID: 10404192 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism.

Nature neuroscience ·Vol. 2 ·No. 7 ·1999-07-00 ·Pages 625-33

Yeckel MF, Kapur A, Johnston D

Abstract

We investigated long-term potentiation (LTP) at mossy fiber synapses on CA3 pyramidal neurons in the hippocampus. Using Ca2+ imaging techniques, we show here that when postsynaptic Ca2+ was sufficiently buffered so that [Ca2+]i did not rise during synaptic stimulation, the induction of mossy fiber LTP was prevented. In addition, induction of mossy fiber LTP was suppressed by postsynaptic injection of a peptide inhibitor of cAMP-dependent protein kinase. Finally, when ionotropic glutamate receptors were blocked, LTP depended on the postsynaptic release of Ca2+ from internal stores triggered by activation of metabotropic glutamate receptors. These results support the conclusion that mossy fiber LTP and LTP at other hippocampal synapses share a common induction mechanism involving an initial rise in postsynaptic [Ca2+].

MeSH Terms
Animals Axons/physiology Calcium/metabolism Chelating Agents/pharmacology Egtazic Acid/analogs & derivatives,pharmacology Electric Stimulation Excitatory Postsynaptic Potentials/physiology Hippocampus/physiology In Vitro Techniques Long-Term Potentiation/drug effects,physiology Nerve Fibers/physiology Patch-Clamp Techniques Pyramidal Cells/physiology Rats Rats, Sprague-Dawley Time Factors
Chemicals
Chelating Agents Egtazic Acid 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yeckel M F
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.
Kapur A
Johnston D
References (48)
48 references, click to expand
  1. Modulation of both the early and the late phase of mossy fiber LTP by the activation of beta-adrenergic receptors.
    Neuron. 1996 Mar;16(3):611-7 PMID: 8785058
  2. A light and electron microscopic analysis of the mossy fibers of the rat dentate gyrus.
    J Comp Neurol. 1986 Apr 22;246(4):435-58 PMID: 3700723
  3. Mossy fiber potentiation and long-term potentiation involve different expression mechanisms.
    Synapse. 1990;5(4):333-5 PMID: 2360200
  4. Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons.
    Nature. 1990 Sep 20;347(6290):281-4 PMID: 2169591
  5. Induction of long-term potentiation at hippocampal mossy-fiber synapses follows a Hebbian rule.
    J Neurophysiol. 1990 Sep;64(3):948-60 PMID: 2230936
  6. Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents.
    Neuron. 1991 Apr;6(4):565-74 PMID: 2015092
  7. High time resolution fluorescence imaging with a CCD camera.
    J Neurosci Methods. 1991 Feb;36(2-3):253-61 PMID: 2062120
  8. Separate mechanisms of long-term potentiation in two input systems to CA3 pyramidal neurons of rat hippocampal slices as revealed by the whole-cell patch-clamp technique.
    Neurosci Res. 1991 Nov;12(3):393-402 PMID: 1686310
  9. NMDA-receptor-independent long-term potentiation.
    Annu Rev Physiol. 1992;54:489-505 PMID: 1314043
  10. N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway.
    Neuroscience. 1992 Jul;49(1):7-11 PMID: 1357588
  11. Mossy fiber long-term potentiation shows specificity but no apparent cooperativity.
    Neurosci Lett. 1992 Apr 13;138(1):193-7 PMID: 1357598
  12. Three-dimensional analysis of the structure and composition of CA3 branched dendritic spines and their synaptic relationships with mossy fiber boutons in the rat hippocampus.
    J Comp Neurol. 1992 Nov 8;325(2):169-82 PMID: 1460112
  13. A synaptic model of memory: long-term potentiation in the hippocampus.
    Nature. 1993 Jan 7;361(6407):31-9 PMID: 8421494
  14. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors.
    Nature. 1993 May 27;363(6427):347-50 PMID: 8388549
  15. Hippocampal circuitry complicates analysis of long-term potentiation in mossy fiber synapses.
    Hippocampus. 1993 Apr;3(2):115-21 PMID: 8353597
  16. Spatial selectivity of unit activity in the hippocampal granular layer.
    Hippocampus. 1993 Apr;3(2):165-82 PMID: 8353604
  17. The role of Ca2+ channels in hippocampal mossy fiber synaptic transmission and long-term potentiation.
    Neuron. 1994 Feb;12(2):261-9 PMID: 8110457
  18. Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.
    Science. 1994 Sep 23;265(5180):1878-82 PMID: 7916482
  19. cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase.
    Cell. 1994 Oct 7;79(1):69-79 PMID: 7923379
  20. Quantal mechanism of long-term potentiation in hippocampal mossy-fiber synapses.
    J Neurophysiol. 1994 Jun;71(6):2552-6 PMID: 7931534
  21. Changes in reliability of synaptic function as a mechanism for plasticity.
    Nature. 1994 Oct 20;371(6499):704-7 PMID: 7935816
  22. Metabotropic glutamate receptor activation induces calcium waves within hippocampal dendrites.
    J Neurophysiol. 1994 Jul;72(1):471-4 PMID: 7965030
  23. Posttetanic potentiation and presynaptically induced long-term potentiation at the mossy fiber synapse in rat hippocampus.
    J Neurobiol. 1995 Mar;26(3):370-85 PMID: 7775970
  24. Evidence for silent synapses: implications for the expression of LTP.
    Neuron. 1995 Aug;15(2):427-34 PMID: 7646894
  25. A presynaptic locus for long-term potentiation of elementary synaptic transmission at mossy fiber synapses in culture.
    Proc Natl Acad Sci U S A. 1996 May 14;93(10):4712-7 PMID: 8643468
  26. Long-term potentiation in cultures of single hippocampal granule cells: a presynaptic form of plasticity.
    Neuron. 1996 Jun;16(6):1147-57 PMID: 8663991
  27. Induction of hebbian and non-hebbian mossy fiber long-term potentiation by distinct patterns of high-frequency stimulation.
    J Neurosci. 1996 Jul 1;16(13):4293-9 PMID: 8753890
  28. Presynaptic long-term depression at the hippocampal mossy fiber-CA3 synapse.
    Science. 1996 Aug 2;273(5275):648-50 PMID: 8662556
  29. Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses.
    J Physiol. 1996 Jun 1;493 ( Pt 2):447-55 PMID: 8782108
  30. Ca2+ release from intracellular stores induced by afferent stimulation of CA3 pyramidal neurons in hippocampal slices.
    J Neurophysiol. 1996 Jul;76(1):554-62 PMID: 8836243
  31. The synaptic activation of kainate receptors.
    Nature. 1997 Jul 10;388(6638):179-82 PMID: 9217158
  32. Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons.
    Nature. 1997 Jul 10;388(6638):182-6 PMID: 9217159
  33. Rab3A is essential for mossy fibre long-term potentiation in the hippocampus.
    Nature. 1997 Aug 7;388(6642):590-3 PMID: 9252190
  34. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus.
    J Neurosci. 1997 Oct 1;17(19):7503-22 PMID: 9295396
  35. Recruitment of new sites of synaptic transmission during the cAMP-dependent late phase of LTP at CA3-CA1 synapses in the hippocampus.
    Neuron. 1997 Sep;19(3):635-51 PMID: 9331354
  36. Mediation of classical conditioning in Aplysia californica by long-term potentiation of sensorimotor synapses.
    Science. 1997 Oct 17;278(5337):467-71 PMID: 9334306
  37. Spatial distribution of potentiated synapses in hippocampus: dependence on cellular mechanisms and network properties.
    J Neurosci. 1998 Jan 1;18(1):438-50 PMID: 9412520
  38. Involvement of presynaptic and postsynaptic mechanisms in a cellular analog of classical conditioning at Aplysia sensory-motor neuron synapses in isolated cell culture.
    J Neurosci. 1998 Jan 1;18(1):458-66 PMID: 9412522
  39. Postsynaptic PKA controls quantal size and reveals a retrograde signal that regulates presynaptic transmitter release in Drosophila.
    Neuron. 1998 Feb;20(2):305-15 PMID: 9491991
  40. L-Type calcium channels are required for one form of hippocampal mossy fiber LTP.
    J Neurophysiol. 1998 Apr;79(4):2181-90 PMID: 9535977
  41. Type I adenylyl cyclase mutant mice have impaired mossy fiber long-term potentiation.
    J Neurosci. 1998 May 1;18(9):3186-94 PMID: 9547227
  42. GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus.
    J Neurosci. 1998 May 1;18(9):3386-403 PMID: 9547246
  43. Neuronal calcium signaling.
    Neuron. 1998 Jul;21(1):13-26 PMID: 9697848
  44. When are class I metabotropic glutamate receptors necessary for long-term potentiation?
    J Neurosci. 1998 Aug 15;18(16):6071-80 PMID: 9698302
  45. Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation.
    J Neurophysiol. 1999 Feb;81(2):781-7 PMID: 10036277
  46. Long-term potentiation of hippocampal mossy fiber synapses is blocked by postsynaptic injection of calcium chelators.
    Neuron. 1989 Nov;3(5):583-8 PMID: 2577129
  47. Comparison of two forms of long-term potentiation in single hippocampal neurons.
    Science. 1990 Jun 29;248(4963):1619-24 PMID: 2114039
  48. Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus.
    J Neurophysiol. 1988 Feb;59(2):667-87 PMID: 2832552
Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1097-6256
DOI
10.1038/10180
Published
1999-07-00
Pages
625-33
Language
English
Region
United States
NLM ID
9809671
PMCID
PMC2951317
Subset
IM
Grants
NIMH NIH HHS · F32 MH011390-03 · United States
NIMH NIH HHS · MH48432 · United States
NIMH NIH HHS · F32 MH011390 · United States
NIMH NIH HHS · MH11390 · United States
NIMH NIH HHS · R37 MH044754 · United States
NIMH NIH HHS · R01 MH048432 · United States
NIMH NIH HHS · MH44754 · United States
External Links
PubMed source DOI: 10.1038/10180 PMC Full Text View journal details
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