Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.

Adaptor Proteins, Signal Transducing Amino Acid Substitution Apoptosis Apoptosis Regulatory Proteins Autoimmune Diseases/enzymology,genetics,immunology Breast Neoplasms Carrier Proteins/physiology Caspase 10 Caspases/genetics Cells, Cultured Child DNA Primers Dendritic Cells/pathology,physiology Fas Ligand Protein Fas-Associated Death Domain Protein Female HeLa Cells Homeostasis Humans Lymphocytes/pathology,physiology Lymphoproliferative Disorders/enzymology,genetics,immunology Membrane Glycoproteins/physiology Mutation, Missense Recombinant Proteins/metabolism Reverse Transcriptase Polymerase Chain Reaction TNF-Related Apoptosis-Inducing Ligand Transfection Tumor Necrosis Factor-alpha/physiology fas Receptor/physiology

Adaptor Proteins, Signal Transducing Apoptosis Regulatory Proteins Carrier Proteins DNA Primers FADD protein, human FASLG protein, human Fas Ligand Protein Fas-Associated Death Domain Protein Membrane Glycoproteins Recombinant Proteins TNF-Related Apoptosis-Inducing Ligand TNFSF10 protein, human Tumor Necrosis Factor-alpha fas Receptor Caspase 10 Caspases CASP10 protein, human