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PMID: 10419844 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The development and therapeutic potential of protein kinase inhibitors.

Current opinion in chemical biology ·Vol. 3 ·No. 4 ·1999-08-00 ·Pages 459-65

Cohen P

Abstract

A number of small cell-permeant protein kinase inhibitors have been developed that have the potential for treating a variety of diseases. The basis for the specificity of several of these drugs has been elucidated and a number are undergoing human clinical trials.

MeSH Terms

Drug Design Enzyme Inhibitors/chemical synthesis,metabolism,therapeutic use Humans Hypertension/drug therapy Immunosuppressive Agents/chemical synthesis,metabolism,therapeutic use Inflammation/drug therapy Neoplasms/drug therapy Phosphorylation Protein Kinase Inhibitors Protein Kinases/metabolism Substrate Specificity

Chemicals

Enzyme Inhibitors Immunosuppressive Agents Protein Kinase Inhibitors Protein Kinases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Cohen P

MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI/WTB Complex, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK. [email protected]

Article Info

Journal

Current opinion in chemical biology

Abbr.

Curr Opin Chem Biol

ISSN

1367-5931

DOI

10.1016/S1367-5931(99)80067-2

[email protected]

Published

1999-08-00

Pages

459-65

Language

English

Region

England

NLM ID

9811312

Subset

External Links

PubMed source DOI: 10.1016/S1367-5931(99)80067-2 View journal details

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The development and therapeutic potential of protein kinase inhibitors.

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