Home LiteratureArticle Details
PMID: 10427001 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Embryonic stem cell-derived glial precursors: a source of myelinating transplants.

Science (New York, N.Y.) ·Vol. 285 ·No. 5428 ·1999-07-30 ·Pages 754-6

Brüstle O, Jones KN, Learish RD, Karram K, Choudhary K, Wiestler OD, Duncan ID, McKay RD

Abstract

Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell-derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation.

MeSH Terms
Animals Astrocytes/cytology Brain/embryology,metabolism Cell Differentiation Cell Line Cell Movement Cerebral Ventricles/embryology,surgery Diffuse Cerebral Sclerosis of Schilder/genetics,therapy Embryo, Mammalian/cytology Growth Substances/pharmacology Humans Male Mice Myelin Basic Protein/biosynthesis Myelin Proteolipid Protein/biosynthesis,genetics Myelin Sheath/physiology Oligodendroglia/cytology,metabolism,transplantation,ultrastructure Rats Spinal Cord Stem Cell Transplantation Stem Cells/cytology
Chemicals
Growth Substances Myelin Basic Protein Myelin Proteolipid Protein
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Brüstle O
Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. [email protected]
Jones K N
Learish R D
Karram K
Choudhary K
Wiestler O D
Duncan I D
McKay R D
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.285.5428.754
Email
[email protected]
Published
1999-07-30
Pages
754-6
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NINDS NIH HHS · NS33710 · United States
Corrections
CommentIn
PMID: 10454911
External Links
PubMed source DOI: 10.1126/science.285.5428.754 View journal details
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