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PMID: 10431158 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction.

Immunology today ·Vol. 20 ·No. 8 ·1999-08-00 ·Pages 375-82

Lupher ML, Rao N, Eck MJ, Band H

Abstract

The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.

MeSH Terms

Animals Humans Leukocytes/immunology,metabolism Models, Biological Models, Molecular Protein Conformation Protein-Tyrosine Kinases/metabolism Proto-Oncogene Proteins/chemistry,immunology,metabolism Proto-Oncogene Proteins c-cbl Receptors, Immunologic/metabolism Signal Transduction/immunology Ubiquitin-Protein Ligases

Chemicals

Proto-Oncogene Proteins Receptors, Immunologic Proto-Oncogene Proteins c-cbl Ubiquitin-Protein Ligases Protein-Tyrosine Kinases CBL protein, human

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Lupher M L

ICOS Corporation, Bothell, WA 98021, USA.

Rao N

Eck M J

Band H

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/s0167-5699(99)01484-x

Published

1999-08-00

Pages

375-82

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/s0167-5699(99)01484-x

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