Pak to the future.

Trends in cell biology ·Vol. 9 ·No. 9 ·1999-09-00 ·Pages 350-5

Bagrodia S, Cerione RA

Abstract

Members of the Pak family of serine/threonine kinases serve as targets for the small GTP-binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. Recently, some exciting developments help elaborate the regulation of Pak activity and identify downstream signalling targets. These include the discovery of the Cool/Pix and Cat proteins, which modulate Pak signalling, and downstream kinases that modulate the organization of the actin cytoskeleton or gene expression. We present these recent findings and consider how these new regulators and targets could explain some of the cellular effects that have been attributed to Pak family members.

MeSH Terms

Adaptor Proteins, Signal Transducing Animals Cell Cycle Proteins/metabolism Cell Nucleus/metabolism Cytoskeleton/metabolism GTP-Binding Proteins/metabolism GTPase-Activating Proteins Gene Expression Regulation Guanine Nucleotide Exchange Factors Intercellular Signaling Peptides and Proteins Macromolecular Substances Models, Biological Oncogene Proteins/physiology Phosphoproteins/metabolism Protein Binding Protein Serine-Threonine Kinases/physiology Rho Guanine Nucleotide Exchange Factors Signal Transduction cdc42 GTP-Binding Protein p21-Activated Kinases rac GTP-Binding Proteins src Homology Domains

Chemicals

Adaptor Proteins, Signal Transducing Cell Cycle Proteins GIT1 protein, human GTPase-Activating Proteins Git2 protein, mouse Guanine Nucleotide Exchange Factors Intercellular Signaling Peptides and Proteins Macromolecular Substances Nck protein Oncogene Proteins Phosphoproteins Rho Guanine Nucleotide Exchange Factors PAK1 protein, human PAK2 protein, human PAK3 protein, human Pak1 protein, mouse Pak2 protein, mouse Pak3 protein, mouse Pak4 protein, mouse Protein Serine-Threonine Kinases p21-Activated Kinases GTP-Binding Proteins cdc42 GTP-Binding Protein rac GTP-Binding Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bagrodia S

Dept of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA.

Cerione R A

Article Info

Journal

Trends in cell biology

Abbr.

Trends Cell Biol

ISSN

0962-8924

DOI

10.1016/s0962-8924(99)01618-9

Published

1999-09-00

Pages

350-5

Language

English

Region

England

NLM ID

9200566

Subset

Corrections

CommentIn

PMID: 10532821

External Links

PubMed source DOI: 10.1016/s0962-8924(99)01618-9 View journal details

Analysis Services

Pak to the future.

Contact

WeChat Official Account