Pax 6: mastering eye morphogenesis and eye evolution.

Trends in genetics : TIG ·Vol. 15 ·No. 9 ·1999-09-00 ·Pages 371-7

Gehring WJ, Ikeo K

Abstract

Pax 6 genes from various animal phyla are capable of inducing ectopic eye development, indicating that Pax 6 is a master control gene for eye morphogenesis. It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution.

MeSH Terms

Amino Acid Sequence Animals Biological Evolution DNA-Binding Proteins/genetics Eye/growth & development Eye Proteins/genetics Homeodomain Proteins Humans Molecular Sequence Data PAX6 Transcription Factor Paired Box Transcription Factors Repressor Proteins Sequence Homology, Amino Acid

Chemicals

DNA-Binding Proteins Eye Proteins Homeodomain Proteins PAX6 Transcription Factor PAX6 protein, human Paired Box Transcription Factors Repressor Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Gehring W J

Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland. [email protected]

Ikeo K

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

DOI

10.1016/s0168-9525(99)01776-x

[email protected]

Published

1999-09-00

Pages

371-7

Language

English

Region

England

NLM ID

8507085

Subset

Corrections

CommentIn

PMID: 10827449

External Links

PubMed source DOI: 10.1016/s0168-9525(99)01776-x View journal details

Analysis Services

Pax 6: mastering eye morphogenesis and eye evolution.

Contact

WeChat Official Account