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PMID: 10498270 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic control of cortical regionalization and connectivity.

Cerebral cortex (New York, N.Y. : 1991) ·Vol. 9 ·No. 6 ·1999-09-00 ·Pages 524-32

Rubenstein JL, Anderson S, Shi L, Miyashita-Lin E, Bulfone A, Hevner R

Abstract

Herein, the genetic control of regionalization and connectivity of the neocortex are reviewed. Evidence is accumulating which suggests that intrinsic mechanisms have a central role in controlling cortical regional specification and differentiation. Expression patterns of several genes (Id-2, Tbr-1, cadherin-6, cadherin-8, neuropilin-2, Wnt-7b, Eph-A7 and RZR-beta) are described; the expressions of these genes have regional boundaries which demarcate distinct functional areas of the cerebral cortex in neonatal mice.

MeSH Terms

Animals Animals, Newborn Axons/chemistry,physiology Biomarkers Brain Stem/cytology Cadherins/genetics DNA-Binding Proteins/genetics Gene Expression Regulation, Developmental Glycoproteins Inhibitor of Differentiation Protein 2 Mice Mice, Inbred Strains Neocortex/cytology,embryology,growth & development Nerve Tissue Proteins/genetics Neural Pathways/cytology,embryology,growth & development Neuropilin-1 Proto-Oncogene Proteins/genetics RNA, Messenger/analysis Receptor Protein-Tyrosine Kinases/genetics Receptor, EphA7 Receptors, Cell Surface/genetics Receptors, Cytoplasmic and Nuclear/genetics Receptors, Melatonin Repressor Proteins Spinal Cord/cytology T-Box Domain Proteins Thalamus/cytology Transcription Factors Wnt Proteins

Chemicals

Biomarkers Cadherins Cdh8 protein, mouse DNA-Binding Proteins Glycoproteins Idb2 protein, mouse Inhibitor of Differentiation Protein 2 Nerve Tissue Proteins Proto-Oncogene Proteins RNA, Messenger Receptors, Cell Surface Receptors, Cytoplasmic and Nuclear Receptors, Melatonin Repressor Proteins T-Box Domain Proteins Tbr1 protein, mouse Transcription Factors Wnt Proteins Wnt7b protein, mouse Neuropilin-1 Receptor Protein-Tyrosine Kinases Receptor, EphA7 K cadherin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Rubenstein J L

Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143-0984, USA. [email protected]

Anderson S

Shi L

Miyashita-Lin E

Bulfone A

Hevner R

Article Info

Journal

Cerebral cortex (New York, N.Y. : 1991)

Abbr.

Cereb Cortex

ISSN

1047-3211

DOI

10.1093/cercor/9.6.524

[email protected]

Published

1999-09-00

Pages

524-32

Language

English

Region

United States

NLM ID

9110718

Subset

Grants

Telethon · F.2 · Italy

NIMH NIH HHS · K02 MH01046-01 · United States

NIMH NIH HHS · K08-MH01620-1 · United States

NINDS NIH HHS · NS34661-01A1 · United States

External Links

PubMed source DOI: 10.1093/cercor/9.6.524 View journal details

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Genetic control of cortical regionalization and connectivity.

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