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PMID: 10498949 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The mar regulon: multiple resistance to antibiotics and other toxic chemicals.

Trends in microbiology ·Vol. 7 ·No. 10 ·1999-10-00 ·Pages 410-3

Alekshun MN, Levy SB

Abstract

The chromosomal multiple antibiotic resistance (mar) locus of Escherichia coli and other members of the Enterobacteriaceae controls resistance to multiple, structurally unrelated compounds including antibiotics, household disinfectants, organic solvents and other toxic chemicals. The Mar phenotype is induced following exposure to a variety of chemicals with aromatic rings.

MeSH Terms
Anti-Bacterial Agents/pharmacology Disinfectants/pharmacology Drug Resistance, Microbial/genetics Drug Resistance, Multiple/genetics Escherichia coli/drug effects,genetics Humans Regulon Solvents/pharmacology
Chemicals
Anti-Bacterial Agents Disinfectants Solvents
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Alekshun M N
Center for Adaptation Genetics and Drug Resistance, Dept of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.
Levy S B
Article Info
Journal
Trends in microbiology
Abbr.
Trends Microbiol
ISSN
0966-842X
Published
1999-10-00
Pages
410-3
Language
English
Region
England
NLM ID
9310916
Subset
IM
Grants
NIGMS NIH HHS · GM 51661 · United States
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