FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.

Cytokine ·Vol. 11 ·No. 10 ·1999-10-00 ·Pages 729-35

Xie MH, Holcomb I, Deuel B, Dowd P, Huang A, Vagts A, Foster J, Liang J, Brush J, Gu Q, Hillan K, Goddard A, Gurney AL

Abstract

We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.

MeSH Terms

Adenocarcinoma Amino Acid Sequence Animals Base Sequence Cell Division Cell Line Chromosomes, Human, Pair 11/genetics Cloning, Molecular Colorectal Neoplasms Fibroblast Growth Factors/chemistry,genetics,metabolism Gene Expression Heparin/pharmacology Humans Molecular Sequence Data Phylogeny Physical Chromosome Mapping Protein Binding/drug effects Protein Sorting Signals RNA, Messenger/analysis,genetics Receptor, Fibroblast Growth Factor, Type 4 Receptors, Fibroblast Growth Factor/genetics,metabolism Recombinant Fusion Proteins/chemistry,metabolism Retina/embryology,metabolism Sequence Alignment Syndrome Tumor Cells, Cultured

Chemicals

FGF19 protein, human Protein Sorting Signals RNA, Messenger Receptors, Fibroblast Growth Factor Recombinant Fusion Proteins Fibroblast Growth Factors Heparin FGFR4 protein, human Receptor, Fibroblast Growth Factor, Type 4

Authors & Affiliations

13 authors, click to expand affiliations / ORCID

Xie M H

Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Holcomb I

Deuel B

Dowd P

Huang A

Vagts A

Foster J

Liang J

Brush J

Gu Q

Hillan K

Goddard A

Gurney A L

Article Info

Journal

Cytokine

Abbr.

Cytokine

ISSN

1043-4666

DOI

10.1006/cyto.1999.0485

Published

1999-10-00

Pages

729-35

Language

English

Region

England

NLM ID

9005353

Subset

Databases

GENBANK

AF110400

External Links

PubMed source DOI: 10.1006/cyto.1999.0485 View journal details

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FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.

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