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PMID: 10550308 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis.

The American journal of pathology ·Vol. 155 ·No. 5 ·1999-11-00 ·Pages 1519-23

Qiu H, Zhang W, El-Naggar AK, Lippman SM, Lin P, Lotan R, Xu XC

Abstract

We recently observed that growth inhibition of esophageal cancer cells by retinoic acid (RA) was associated with both constitutive expression and RA-induced up-regulation of RA receptor beta (RAR-beta). Cell lines that did not express RAR-beta were also resistant to RA. To explore the expression of RAR-beta mRNA in vivo, we analyzed esophageal tissue specimens from 16 normal mucosae, 30 dysplastic lesions, and 157 esophageal tumors by in situ hybridization. RAR-beta was detected in 88% (14/16) of normal esophageal tissues and in 96% (96/100) of distant normal esophageal mucosa from cancer specimens. In contrast, RAR-beta was expressed in only 57% (17/30) of dysplastic lesions and in 54% (84/157) of carcinomas. Among esophageal carcinomas RAR-beta mRNA was expressed in 62% (26/42) of well-differentiated, 54% (27/50) of moderately differentiated, and only 29% (4/14) of poorly differentiated SCCs. Our data suggest that the loss of RAR-beta expression is an early event associated with esophageal carcinogenesis and the status of squamous differentiation.

MeSH Terms
Aged Cell Differentiation/genetics Esophageal Neoplasms/genetics,metabolism,pathology Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Male Middle Aged Receptors, Retinoic Acid/biosynthesis,genetics Up-Regulation
Chemicals
Receptors, Retinoic Acid retinoic acid receptor beta
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Qiu H
Departments of Clinical Cancer Prevention, Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Zhang W
El-Naggar A K
Lippman S M
Lin P
Lotan R
Xu X C
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20 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
DOI
10.1016/s0002-9440(10)65467-3
Published
1999-11-00
Pages
1519-23
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1866961
Subset
IM
Grants
NCI NIH HHS · R29 CA074835 · United States
NCI NIH HHS · CA74835 · United States
External Links
PubMed source DOI: 10.1016/s0002-9440(10)65467-3 PMC Full Text View journal details
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