Class II-independent generation of CD4 memory T cells from effectors.

Science (New York, N.Y.) ·Vol. 286 ·No. 5443 ·1999-11-12 ·Pages 1381-3

Swain SL, Hu H, Huston G

Abstract

The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.

MeSH Terms

Adoptive Transfer Animals Cell Division Cytokines/biosynthesis Histocompatibility Antigens Class II/immunology Immunization Immunologic Memory Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Receptors, Antigen, T-Cell/immunology T-Lymphocyte Subsets/cytology,immunology Th1 Cells/cytology,immunology Th2 Cells/cytology,immunology

Chemicals

Cytokines Histocompatibility Antigens Class II Receptors, Antigen, T-Cell

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Swain S L

Biomedical Research Laboratories, Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA. [email protected]

Hu H

Huston G

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.286.5443.1381

[email protected]

Published

1999-11-12

Pages

1381-3

Language

English

Region

United States

NLM ID

0404511

Subset

Corrections

CommentIn

PMID: 10610529

External Links

PubMed source DOI: 10.1126/science.286.5443.1381 View journal details

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Class II-independent generation of CD4 memory T cells from effectors.

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