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PMID: 1058173 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Distinctive banded marker chromosomes of human tumor cell lines.

International journal of cancer ·Vol. 16 ·No. 1 ·1975-07-15 ·Pages 74-82

Nelson-Rees WA, Flandermeyer RR, Hawthorne PK

Abstract

Nine human tumor cell lines (five breast carcinomas and four sarcomas) have been studied and each revealed groups of distinctive banded marker chromosomes which can serve to identify them and aid in monitoring cell line specificity. This was possible neither by conventional karyology in terms of numbers and morphology of chromosomes nor by glucose-6-phosphate-dehydrogenase mobility which was type B for all cultures. The significance of the clonal nature of the cell lines is discussed.

MeSH Terms

Breast Neoplasms/genetics Carcinoma/genetics Cell Line Chromosome Aberrations Female Fibrosarcoma/genetics Glucosephosphate Dehydrogenase/metabolism Humans In Vitro Techniques Isoenzymes/metabolism Karyotyping Liposarcoma/genetics Male Osteosarcoma/genetics Rhabdomyosarcoma/genetics Sarcoma/genetics Sex Chromosomes Translocation, Genetic

Chemicals

Isoenzymes Glucosephosphate Dehydrogenase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Nelson-Rees W A

Flandermeyer R R

Hawthorne P K

Article Info

Journal

International journal of cancer

Abbr.

Int J Cancer

ISSN

0020-7136

DOI

10.1002/ijc.2910160109

Published

1975-07-15

Pages

74-82

Language

English

Region

United States

NLM ID

0042124

Subset

External Links

PubMed source DOI: 10.1002/ijc.2910160109 View journal details

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