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PMID: 1058479 Published · ppublish English Journal Article

Minimal requirements for template recognition by bacteriophage Qbeta replicase: approach to general RNA-dependent RNA synthesis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 7 ·1975-07-00 ·Pages 2640-3

Küppers B, Sumper M

Abstract

Any oligo- or polynucleotide able to offer a C-C-C-sequence at the 3'-terminus and a second C-C-C-sequence in a defined steric position to Qbeta replicase is an efficient template. Corresponding chemical modifications convert non-template RNAs to template RNAs.

MeSH Terms
Base Sequence Coliphages/enzymology Nucleic Acid Conformation Oligoribonucleotides/analysis Q beta Replicase/metabolism RNA Nucleotidyltransferases/metabolism RNA Viruses/enzymology RNA, Viral/biosynthesis RNA-Dependent RNA Polymerase/metabolism Templates, Genetic
Chemicals
Oligoribonucleotides RNA, Viral Q beta Replicase RNA Nucleotidyltransferases RNA-Dependent RNA Polymerase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Küppers B
Sumper M
References (18)
18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.7.2640
Published
1975-07-00
Pages
2640-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432825
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.7.2640 PMC Full Text View journal details
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