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PMID: 106304 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.

Nature ·Vol. 277 ·No. 5698 ·1979-02-22 ·Pages 627-33

Sakano H, Rogers JH, Hüppi K, Brack C, Traunecker A, Maki R, Wall R, Tonegawa S

Abstract

A 6.8-kilobase DNA fragment containing the sequence coding for the constant region of the mouse immunoglobulin gamma1 heavy chain was cloned from total cellular DNA. Electron microscopic and nucleotide sequencing studies showed that the three protein domains and the hinge region are encoded in separate DNA segments.

MeSH Terms
Animals Base Sequence Biological Evolution Chromosome Deletion DNA, Recombinant Genes Genetic Linkage Immunoglobulin Heavy Chains/genetics Immunoglobulin gamma-Chains/genetics Mice Mutation Myeloma Proteins/genetics
Chemicals
DNA, Recombinant Immunoglobulin Heavy Chains Immunoglobulin gamma-Chains Myeloma Proteins
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Sakano H
Rogers J H
Hüppi K
Brack C
Traunecker A
Maki R
Wall R
Tonegawa S
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/277627a0
Published
1979-02-22
Pages
627-33
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
J00453
External Links
PubMed source DOI: 10.1038/277627a0 View journal details
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