Home LiteratureArticle Details
PMID: 10634209 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

TNF-induced signaling in apoptosis.

Journal of clinical immunology ·Vol. 19 ·No. 6 ·1999-11-00 ·Pages 350-64

Rath PC, Aggarwal BB

Abstract

Out of the almost 17 members of the TNF superfamily, TNF is probably the most potent inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms simultaneously. Activation of NF-kB-dependent genes regulates the survival and proliferative effects pf TNF, whereas activation of caspases regulates the apoptotic effects. TNF-induced apoptosis is mediated primarily through the activation of type I receptors, the death domain of which recruits more than a dozen different signaling proteins, which together are considered part of an apoptotic cascade. This cascade does not, however, account for the role of reactive oxygen intermediates, ceramide, phospholipases, and serine proteases which are also implicated in TNF-induced apoptosis. This cascade also does not explain how type II TNF receptors which lack the death domain, induce apoptosis. Nevertheless, this review of apoptosis signaling will be limited to those proteins that makeup the cascade.

MeSH Terms
Animals Apoptosis/drug effects Arabidopsis Proteins Caspase 8 Caspase 9 Caspases/physiology Ceramides/physiology Fatty Acid Desaturases/physiology Humans Phospholipases/physiology Protein Biosynthesis Proteins/physiology Reactive Oxygen Species Receptors, Tumor Necrosis Factor/physiology TNF Receptor-Associated Factor 1 Tumor Necrosis Factor-alpha/pharmacology
Chemicals
Arabidopsis Proteins Ceramides Proteins Reactive Oxygen Species Receptors, Tumor Necrosis Factor TNF Receptor-Associated Factor 1 Tumor Necrosis Factor-alpha Fatty Acid Desaturases Fad7 protein, Arabidopsis Phospholipases CASP8 protein, human CASP9 protein, human Caspase 8 Caspase 9 Caspases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rath P C
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Aggarwal B B
References (203)
203 references, click to expand
  1. Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology.
    J Immunol. 1996 Nov 1;157(9):4109-18 PMID: 8892646
  2. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis.
    J Virol. 1998 May;72(5):3691-7 PMID: 9557650
  3. RIP3, a novel apoptosis-inducing kinase.
    J Biol Chem. 1999 Jun 11;274(24):16871-5 PMID: 10358032
  4. Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis.
    Antioxid Redox Signal. 1999 Summer;1(2):181-91 PMID: 11228746
  5. Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase.
    J Biol Chem. 1999 Feb 26;274(9):5267-70 PMID: 10026132
  6. Epidermal growth factor inhibits cytokine-induced apoptosis of primary human trophoblasts.
    J Cell Physiol. 1996 May;167(2):324-32 PMID: 8613474
  7. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.
    Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8115-9 PMID: 7667254
  8. Activation of the insulin-like growth factor-I receptor inhibits tumor necrosis factor-induced cell death.
    J Cell Physiol. 1996 Sep;168(3):499-509 PMID: 8816904
  9. Cell death: the significance of apoptosis.
    Int Rev Cytol. 1980;68:251-306 PMID: 7014501
  10. Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.
    Cancer Res. 1995 Mar 1;55(5):991-4 PMID: 7867010
  11. Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor.
    J Biol Chem. 1993 May 25;268(15):11290-5 PMID: 7684376
  12. MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.
    J Biol Chem. 1997 May 2;272(18):12069-75 PMID: 9115275
  13. TNF-alpha-mediated apoptosis is initiated in caveolae-like domains.
    J Immunol. 1999 Jun 15;162(12):7217-23 PMID: 10358168
  14. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains.
    Science. 1999 Jan 22;283(5401):543-6 PMID: 9915703
  15. Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever.
    J Gen Virol. 1997 Mar;78 ( Pt 3):677-85 PMID: 9049422
  16. Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells.
    J Biol Chem. 1998 Sep 25;273(39):25198-202 PMID: 9737981
  17. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
    Cell. 1995 May 19;81(4):505-12 PMID: 7538907
  18. Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.
    Cytokine. 1998 Jun;10(6):423-31 PMID: 9632528
  19. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation.
    Biochem Cell Biol. 1994 Nov-Dec;72(11-12):471-4 PMID: 7544586
  20. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.
    Cell. 1995 May 19;81(4):495-504 PMID: 7758105
  21. Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor toxicity.
    Gastroenterology. 1998 Nov;115(5):1229-37 PMID: 9797379
  22. TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival.
    Immunity. 1997 Nov;7(5):703-13 PMID: 9390693
  23. Expression of the 75 kDA TNF receptor and its role in contact-mediated neuronal cell death.
    Brain Res Mol Brain Res. 1998 Nov 20;62(2):111-21 PMID: 9813268
  24. Apaf1 is required for mitochondrial pathways of apoptosis and brain development.
    Cell. 1998 Sep 18;94(6):739-50 PMID: 9753321
  25. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.
    Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3792-7 PMID: 9520446
  26. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
    Science. 1998 Mar 20;279(5358):1954-8 PMID: 9506948
  27. Suppression of TNF-alpha-induced apoptosis by NF-kappaB.
    Science. 1996 Nov 1;274(5288):787-9 PMID: 8864120
  28. Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells.
    Eur J Immunol. 1998 Nov;28(11):3577-86 PMID: 9842900
  29. Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB.
    J Biol Chem. 1997 Jun 27;272(26):16474-81 PMID: 9195956
  30. The effects of human recombinant tumor necrosis factor on glioma-derived cell lines: cellular proliferation, cytotoxicity, morphological and radioreceptor studies.
    Int J Cancer. 1988 Apr 15;41(4):573-82 PMID: 2833452
  31. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.
    Immunity. 1998 Mar;8(3):297-303 PMID: 9529147
  32. Altered susceptibility to tumor necrosis factor alpha-induced apoptosis of mouse cells expressing polyomavirus middle and small T antigens.
    J Virol. 1997 Jan;71(1):276-83 PMID: 8985347
  33. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors.
    J Biol Chem. 1999 Jun 18;274(25):17484-90 PMID: 10364179
  34. Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1.
    J Biol Chem. 1996 Nov 1;271(44):27201-4 PMID: 8910286
  35. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
    J Biol Chem. 1998 May 1;273(18):11313-20 PMID: 9556624
  36. TNF-alpha activates at least two apoptotic signaling cascades.
    Oncogene. 1998 Oct 1;17(13):1639-51 PMID: 9796693
  37. Tumor necrosis factor-alpha-induced apoptosis in a human keratinocyte cell line (HaCaT) is counteracted by transforming growth factor-alpha.
    Exp Cell Res. 1996 Nov 1;228(2):334-40 PMID: 8912727
  38. Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene.
    FEBS Lett. 1995 Jan 2;357(1):1-6 PMID: 8001667
  39. Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.
    Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8318-22 PMID: 7667287
  40. Butylated hydroxyanisole specifically inhibits tumor necrosis factor-induced cytotoxicity and growth enhancement.
    Cytokine. 1992 Jul;4(4):269-80 PMID: 1515551
  41. Tumor necrosis factor-alpha up-regulates Bcl-2 expression and decreases calcium-dependent apoptosis in human B cell lines.
    Int Immunol. 1995 Apr;7(4):533-40 PMID: 7547679
  42. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.
    Nature. 1996 Nov 28;384(6607):368-72 PMID: 8934524
  43. Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis.
    J Biol Chem. 1997 Jan 17;272(3):1965-9 PMID: 8999887
  44. TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20.
    Free Radic Biol Med. 1998 Jul 1 ;25(1):57-65 PMID: 9655522
  45. Involvement of two types of TNF receptor in TNF-alpha induced neutrophil apoptosis.
    Microbiol Immunol. 1996;40(6):463-5 PMID: 8839434
  46. Differential requirement for caspase 9 in apoptotic pathways in vivo.
    Cell. 1998 Aug 7;94(3):339-52 PMID: 9708736
  47. Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.
    EMBO J. 1992 Oct;11(10):3507-12 PMID: 1396553
  48. Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function.
    Oncogene. 1997 Dec 4;15(23 ):2817-26 PMID: 9419972
  49. Tumor necrosis factor receptor and Fas signaling mechanisms.
    Annu Rev Immunol. 1999;17 :331-67 PMID: 10358762
  50. Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro.
    Blood. 1997 Oct 1;90(7):2772-83 PMID: 9326245
  51. The p80 TNF receptor-associated kinase (p80TRAK) associates with residues 354-397 of the p80 cytoplasmic domain: similarity to casein kinase.
    FEBS Lett. 1997 Apr 7;406(1-2):101-5 PMID: 9109395
  52. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition.
    J Biol Chem. 1996 Nov 22;271(47):29792-8 PMID: 8939917
  53. Overexpression of manganese-containing superoxide dismutase confers resistance to the cytotoxicity of tumor necrosis factor alpha and/or hyperthermia.
    Cancer Res. 1997 May 15;57(10):1991-8 PMID: 9157996
  54. Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes.
    Eur J Biochem. 1998 Oct 1;257(1):47-54 PMID: 9799101
  55. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein.
    J Biol Chem. 1998 Jan 23;273(4):2256-9 PMID: 9442069
  56. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.
    Cell. 1999 Apr 2;97(1):133-44 PMID: 10199409
  57. Programmed cell death induced by ceramide.
    Science. 1993 Mar 19;259(5102):1769-71 PMID: 8456305
  58. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha.
    Immunol Lett. 1997 Jan;55(1):5-10 PMID: 9093874
  59. Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling.
    Biochem Pharmacol. 1998 Oct 15;56(8):915-20 PMID: 9776301
  60. Ceramide in apoptosis--does it really matter?
    Trends Biochem Sci. 1998 Oct;23(10):374-7 PMID: 9810222
  61. Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation.
    Blood. 1995 Sep 15;86(6):2248-56 PMID: 7662972
  62. Contenders in FasL/TNF death signaling.
    Cell. 1995 May 19;81(4):479-82 PMID: 7758103
  63. A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway.
    J Biol Chem. 1996 Jun 14;271(24):14617-22 PMID: 8663014
  64. Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates.
    J Biol Chem. 1998 May 29;273(22):14008-14 PMID: 9593751
  65. The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.
    J Clin Invest. 1998 May 15;101(10 ):2278-89 PMID: 9593784
  66. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.
    J Biol Chem. 1999 Feb 19;274(8):5053-60 PMID: 9988752
  67. Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis.
    Oncogene. 1998 Nov 12;17(19):2515-24 PMID: 9824162
  68. Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.
    Cytokine. 1997 Sep;9(9):631-8 PMID: 9325011
  69. Efficient adenoviral transfer of NF-kappaB inhibitor sensitizes melanoma to tumor necrosis factor-mediated apoptosis.
    Int J Cancer. 1999 Jan 18;80(2):320-3 PMID: 9935217
  70. Resistance to cytolysis by tumor necrosis factor alpha in malignant gynecological cell lines is associated with the expression of protein(s) that prevent the activation of phospholipase A2 by tumor necrosis factor alpha.
    Cancer Res. 1992 Feb 15;52(4):866-72 PMID: 1737348
  71. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control.
    Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10057-62 PMID: 9294162
  72. Tumor necrosis factor receptor-mediated signaling pathways.
    J Cell Biol. 1994 Jul;126(1):5-9 PMID: 8027185
  73. Evidence that protein kinase Cepsilon mediates phorbol ester inhibition of calphostin C- and tumor necrosis factor-alpha-induced apoptosis in U937 histiocytic lymphoma cells.
    J Biol Chem. 1998 Sep 11;273(37):24115-21 PMID: 9727032
  74. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1.
    J Biol Chem. 1998 May 22;273(21):13245-54 PMID: 9582369
  75. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand.
    J Biol Chem. 1998 Oct 30;273(44):29247-53 PMID: 9786937
  76. Tumor necrosis factor-alpha induces p53-dependent apoptosis in rat glioma cells.
    Neurosurgery. 1995 Oct;37(4):758-62; discussion 762-3 PMID: 8559306
  77. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.
    J Exp Med. 1999 Jun 7;189(11):1839-45 PMID: 10359587
  78. Differential expression and translocation of protein tyrosine phosphatase 1B-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor necrosis factor: potential interaction with epidermal growth factor receptor.
    Oncogene. 1999 Jan 28;18(4):967-78 PMID: 10023672
  79. A novel Arabidopsis thaliana protein protects tumor cells from tumor necrosis factor-induced apoptosis.
    Biochim Biophys Acta. 1998 Mar 12;1402(1):70-8 PMID: 9551087
  80. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis.
    Exp Cell Res. 1994 Oct;214(2):584-94 PMID: 7925652
  81. Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells.
    Cancer Res. 1992 May 1;52(9):2557-62 PMID: 1314698
  82. Ras signaling in tumor necrosis factor-induced apoptosis.
    EMBO J. 1996 Sep 2;15(17):4497-505 PMID: 8887541
  83. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha.
    J Biol Chem. 1998 Apr 24;273(17):10232-9 PMID: 9553074
  84. Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase.
    J Biol Chem. 1996 Jun 14;271(24):14560-6 PMID: 8662985
  85. TRAF6 is a signal transducer for interleukin-1.
    Nature. 1996 Oct 3;383(6599):443-6 PMID: 8837778
  86. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.
    Cell. 1998 Aug 7;94(3):325-37 PMID: 9708735
  87. Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
    FEBS Lett. 1994 Oct 31;354(1):12-6 PMID: 7957892
  88. CD40 induces resistance to TNF-mediated apoptosis in a fibroblast cell line.
    Eur J Immunol. 1998 Nov;28(11):3594-604 PMID: 9842902
  89. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA.
    Mol Cell Biol. 1995 May;15(5):2359-66 PMID: 7739519
  90. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor.
    Cell. 1989 Sep 8;58(5):923-31 PMID: 2476237
  91. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality.
    Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2994-9 PMID: 10077625
  92. Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation.
    EMBO J. 1997 Dec 15;16(24):7382-92 PMID: 9405367
  93. Failure to activate cytosolic phospholipase A2 causes TNF resistance in human leukemic cells.
    J Immunol. 1998 Jun 15;160(12 ):5929-35 PMID: 9637506
  94. Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function.
    J Biol Chem. 1995 Nov 17;270(46):27894-904 PMID: 7499264
  95. An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.
    Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12451-5 PMID: 8901602
  96. Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1.
    Oncogene. 1999 Jul 29;18(30):4371-82 PMID: 10439045
  97. Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells.
    J Nat Prod. 1997 Aug;60(8):775-8 PMID: 9287415
  98. Potentiation of tumor necrosis factor induced apoptosis by onconase.
    Int J Oncol. 1998 Jul;13(1):11-6 PMID: 9625797
  99. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release.
    J Immunol. 1995 Feb 1;154(3):1307-16 PMID: 7822799
  100. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.
    Science. 1999 Apr 2;284(5411):156-9 PMID: 10102818
  101. Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2.
    J Biol Chem. 1998 Nov 20;273(47):31262-72 PMID: 9813034
  102. Prevention of tumor necrosis factor (TNF)-mediated induction of p21WAF1/CIP1 sensitizes MCF-7 carcinoma cells to TNF-induced apoptosis.
    Biochem Biophys Res Commun. 1998 Apr 28;245(3):691-7 PMID: 9588176
  103. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.
    Oncogene. 1995 Jun 15;10 (12 ):2297-305 PMID: 7540278
  104. Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis.
    J Biol Chem. 1995 Oct 6;270(40):23293-9 PMID: 7559483
  105. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha.
    Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8744-9 PMID: 9238048
  106. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.
    Cell. 1996 Jan 26;84(2):299-308 PMID: 8565075
  107. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
    EMBO J. 1993 Aug;12(8):3095-104 PMID: 8344250
  108. Activation of intracellular proteases is an early event in TNF-induced apoptosis.
    J Immunol. 1995 Feb 15;154(4):1707-16 PMID: 7836755
  109. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release.
    Mol Cell Biol. 1998 Nov;18(11):6353-64 PMID: 9774651
  110. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling.
    Cell. 1994 May 6;77(3):325-8 PMID: 8181053
  111. Suicidal tendencies: apoptotic cell death by caspase family proteinases.
    J Biol Chem. 1999 Jul 16;274(29):20049-52 PMID: 10400609
  112. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
    Cell. 1996 Jun 14;85(6):817-27 PMID: 8681377
  113. Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition.
    J Virol. 1997 Mar;71(3):2171-81 PMID: 9032351
  114. Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity.
    Biochem Biophys Res Commun. 1998 Dec 30;253(3):743-9 PMID: 9918798
  115. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40.
    Science. 1995 Sep 8;269(5229):1424-7 PMID: 7544915
  116. Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function.
    J Clin Invest. 1997 Apr 1;99(7):1751-8 PMID: 9120020
  117. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.
    J Immunol. 1998 Apr 1;160(7):3152-62 PMID: 9531270
  118. Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells.
    Proc Natl Acad Sci U S A. 1988 Jul;85(14):5102-6 PMID: 2899323
  119. BRE: a modulator of TNF-alpha action.
    FASEB J. 1998 Sep;12(12):1101-8 PMID: 9737713
  120. C-JUN/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells.
    Oncol Res. 1995;7(7-8):353-62 PMID: 8747598
  121. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
    Cell. 1996 Jun 14;85(6):803-15 PMID: 8681376
  122. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival.
    Science. 1998 Aug 14;281(5379):998-1001 PMID: 9703517
  123. Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.
    Science. 1998 Oct 9;282(5387):290-3 PMID: 9765154
  124. Restoration of E2F expression rescues vascular endothelial cells from tumor necrosis factor-alpha-induced apoptosis.
    Circulation. 1998 Dec 22-29;98(25):2883-90 PMID: 9860791
  125. Influence of cycloheximide-mediated downregulation of glucose transport on TNF alpha-induced apoptosis.
    Exp Cell Res. 1997 Oct 10;236(1):223-30 PMID: 9344602
  126. Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death.
    J Biol Chem. 1997 Apr 11;272(15):9613-6 PMID: 9092486
  127. Two tumour necrosis factor receptors: structure and function.
    Trends Cell Biol. 1995 Oct;5(10):392-9 PMID: 14732063
  128. Induction of programmed cell death by parvovirus H-1 in U937 cells: connection with the tumor necrosis factor alpha signalling pathway.
    J Virol. 1998 Nov;72(11):8893-903 PMID: 9765434
  129. TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.
    Genes Dev. 1996 Apr 15;10(8):963-73 PMID: 8608943
  130. A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis.
    Blood. 1998 Apr 1;91(7):2249-58 PMID: 9516122
  131. Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants.
    J Cell Biochem. 1993 Nov;53(3):222-33 PMID: 8263039
  132. Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone.
    Biochem Pharmacol. 1999 Apr 1;57(7):763-74 PMID: 10075082
  133. Epstein-Barr virus BHRF1 protein protects intestine 407 epithelial cells from apoptosis induced by tumor necrosis factor alpha and anti-Fas antibody.
    J Virol. 1997 Apr;71(4):3319-22 PMID: 9060702
  134. Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells.
    J Biol Chem. 1998 Feb 27;273(9):5067-72 PMID: 9478957
  135. Protein kinase C inhibitors augment tumor-necrosis-factor-induced apoptosis in normal human diploid cells.
    Chemotherapy. 1997 Nov-Dec;43(6):415-23 PMID: 9395855
  136. The bovine papillomavirus type 1 E6 oncoprotein sensitizes cells to tumor necrosis factor alpha-induced apoptosis.
    Oncogene. 1999 Jan 21;18(3):607-15 PMID: 9989810
  137. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.
    EMBO J. 1996 Aug 1;15(15):3861-70 PMID: 8670891
  138. v-Rel prevents apoptosis in transformed lymphoid cells and blocks TNFalpha-induced cell death.
    Oncogene. 1997 Aug 18;15(8):971-80 PMID: 9285692
  139. Cyclin D3 sensitizes tumor cells to tumor necrosis factor-induced, c-Myc-dependent apoptosis.
    Mol Cell Biol. 1996 Oct;16(10):5245-53 PMID: 8816437
  140. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD.
    Nature. 1998 Jan 1;391(6662):43-50 PMID: 9422506
  141. The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis.
    Br J Cancer. 1998 Apr;77(7):1103-7 PMID: 9569046
  142. Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells.
    J Biol Chem. 1997 Jul 4;272(27):17196-203 PMID: 9202042
  143. TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase.
    J Biol Chem. 1998 Mar 6;273(10):5916-22 PMID: 9488730
  144. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.
    Cancer Res. 1998 Apr 15;58(8):1593-8 PMID: 9563466
  145. Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation.
    J Immunol. 1996 Jul 1;157(1):297-304 PMID: 8683130
  146. 1,25-Dihydroxyvitamin D3 protects human leukemic cells from tumor necrosis factor-induced apoptosis via inactivation of cytosolic phospholipase A2.
    Cancer Res. 1998 Feb 15;58(4):633-40 PMID: 9485014
  147. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1.
    Nature. 1998 Mar 19;392(6673):296-300 PMID: 9521326
  148. Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine.
    J Biol Chem. 1996 Nov 8;271(45):28624-9 PMID: 8910494
  149. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB.
    Science. 1996 Nov 1;274(5288):784-7 PMID: 8864119
  150. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase.
    Cell. 1996 Sep 20;86(6):937-47 PMID: 8808629
  151. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
    Cell. 1995 Dec 1;83(5):793-802 PMID: 8521496
  152. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
    J Biol Chem. 1995 Feb 24;270(8):3574-81 PMID: 7876093
  153. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.
    Science. 1996 Nov 1;274(5288):782-4 PMID: 8864118
  154. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.
    Science. 1999 Apr 9;284(5412):316-20 PMID: 10195896
  155. The involvement of novel protein kinase C isozymes in influencing sensitivity of breast cancer MCF-7 cells to tumor necrosis factor-alpha.
    Mol Pharmacol. 1998 Jan;53(1):105-11 PMID: 9443937
  156. Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease.
    J Immunol. 1997 May 1;158(9):4252-9 PMID: 9126987
  157. Induction of receptors for tumor necrosis factor-alpha by interferons is not a major mechanism for their synergistic cytotoxic response.
    J Biol Chem. 1987 Jul 25;262(21):10000-7 PMID: 2440858
  158. Augmentation of antitumor efficacy by the combination of recombinant tumor necrosis factor and chemotherapeutic agents in vivo.
    Cancer Res. 1989 Jul 15;49(14):3729-33 PMID: 2736513
  159. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
    Cell. 1995 Jun 2;81(5):801-9 PMID: 7774019
  160. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.
    Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6346-51 PMID: 9177220
  161. Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.
    J Immunol. 1995 Mar 15;154(6):2904-13 PMID: 7876558
  162. Effects of clusterin overexpression on TNFalpha- and TGFbeta-mediated death of L929 cells.
    Biochemistry. 1997 Dec 9;36(49):15233-43 PMID: 9398251
  163. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide.
    J Neurochem. 1998 Jul;71(1):88-94 PMID: 9648854
  164. The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis.
    J Biol Chem. 1999 Apr 9;274(15):10145-53 PMID: 10187798
  165. TNFalpha potentiates IFNgamma-induced cell death in oligodendrocyte progenitors.
    J Neurosci Res. 1998 Dec 1;54(5):574-83 PMID: 9843148
  166. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.
    J Exp Med. 1998 Jul 6;188(1):211-6 PMID: 9653098
  167. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression.
    J Biol Chem. 1997 Jan 10;272(2):1402-11 PMID: 8995451
  168. Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells.
    J Biol Chem. 1998 Feb 13;273(7):4027-34 PMID: 9461593
  169. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases.
    Science. 1997 Nov 28;278(5343):1630-2 PMID: 9374464
  170. Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor-induced apoptosis in vivo and in vitro.
    Hepatology. 1998 Jun;27(6):1584-91 PMID: 9620331
  171. Alpha 1-acid glycoprotein and alpha 1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice.
    J Immunol. 1997 Oct 1;159(7):3555-64 PMID: 9317155
  172. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis.
    J Biol Chem. 1998 Apr 17;273(16):9357-60 PMID: 9545256
  173. Transfection of cells with basic fibroblast growth factor and Kaposi fibroblast growth factor genes induce resistance to and receptor modulation of tumor necrosis factor.
    FEBS Lett. 1995 Sep 18;372(1):44-8 PMID: 7556640
  174. Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I.
    J Exp Med. 1999 Jun 7;189(11):1707-14 PMID: 10359574
  175. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase.
    J Biol Chem. 1997 Feb 28;272(9):5861-70 PMID: 9038203
  176. The adenovirus E3-14.7K protein and the E3-10.4K/14.5K complex of proteins, which independently inhibit tumor necrosis factor (TNF)-induced apoptosis, also independently inhibit TNF-induced release of arachidonic acid.
    J Virol. 1996 Aug;70(8):4904-13 PMID: 8763993
  177. Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice.
    EMBO J. 1999 May 4;18(9):2472-9 PMID: 10228161
  178. IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.
    J Immunol. 1998 Sep 15;161(6):2863-72 PMID: 9743347
  179. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB.
    Nat Med. 1999 Apr;5(4):412-7 PMID: 10202930
  180. Wortmannin enhances tumour necrosis factor alpha-stimulated neutrophil apoptosis.
    Biochem Soc Trans. 1996 Feb;24(1):80S PMID: 8674761
  181. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.
    Cell. 1995 May 19;81(4):513-23 PMID: 7538908
  182. Effects of growth factors on the antiproliferative activity of tumor necrosis factors.
    Cancer Res. 1987 Feb 1;47(3):780-6 PMID: 3802082
  183. Interleukin-4 down-regulates both forms of tumor necrosis factor receptor and receptor-mediated apoptosis, NF-kappaB, AP-1, and c-Jun N-terminal kinase. Comparison with interleukin-13.
    J Biol Chem. 1998 Dec 11;273(50):33333-41 PMID: 9837907
  184. The central effectors of cell death in the immune system.
    Annu Rev Immunol. 1999;17:781-828 PMID: 10358774
  185. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling.
    Cell. 1994 Sep 23;78(6):1005-15 PMID: 7923351
  186. The p60 tumor necrosis factor (TNF) receptor-associated kinase (TRAK) binds residues 344-397 within the cytoplasmic domain involved in TNF signaling.
    J Biol Chem. 1995 Jun 23;270(25):14867-70 PMID: 7797464
  187. pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
    FEBS Lett. 1994 May 30;345(2-3):219-24 PMID: 7911089
  188. Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death.
    EMBO J. 1999 Jan 15;18(2):353-62 PMID: 9889192
  189. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
    Immunity. 1998 Aug;9(2):267-76 PMID: 9729047
  190. Gangliosides protect from TNF alpha-induced apoptosis.
    Immunol Lett. 1993 Mar;35(3):207-12 PMID: 8514331
  191. Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants.
    Cancer Res. 1998 Nov 1;58(21):4940-6 PMID: 9810003
  192. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.
    Immunity. 1997 Nov;7(5):715-25 PMID: 9390694
  193. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.
    J Biol Chem. 1992 Jun 25;267(18):12424-7 PMID: 1618749
  194. 2-Deoxy-D-glucose enhances sensitivity of human histiocytic lymphoma U937 cells to apoptosis induced by tumor necrosis factor.
    Cancer Res. 1995 Jan 15;55(2):444-9 PMID: 7812976
  195. CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis.
    J Biol Chem. 1995 Aug 11;270(32):18738-41 PMID: 7543896
  196. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis.
    Am J Physiol. 1998 Oct;275(4 Pt 1):C1058-66 PMID: 9755059
  197. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.
    Science. 1998 Sep 11;281(5383):1680-3 PMID: 9733516
  198. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
    Nature. 1999 Jun 10;399(6736):549-57 PMID: 10376594
  199. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
    Science. 1997 Jan 3;275(5296):90-4 PMID: 8974401
  200. Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction.
    J Biol Chem. 1998 Jul 10;273(28):17477-82 PMID: 9651337
  201. Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.
    J Immunol. 1996 Nov 15;157(10):4277-81 PMID: 8906799
  202. The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.
    J Biol Chem. 1998 Apr 17;273(16):9673-80 PMID: 9545301
  203. MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.
    Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11333-8 PMID: 9326610
Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1023/a:1020546615229
Published
1999-11-00
Pages
350-64
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1020546615229 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2