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PMID: 10638995 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Patterns of infection and day care utilization and risk of childhood acute lymphoblastic leukaemia.

British journal of cancer ·Vol. 82 ·No. 1 ·2000-01-00 ·Pages 234-40

Neglia JP, Linet MS, Shu XO, Severson RK, Potter JD, Mertens AC, Wen W, Kersey JH, Robison LL

Abstract

To investigate if decreased exposure to common childhood infections is associated with risk of childhood acute lymphoblastic leukaemia (ALL) we conducted a case-control study of 1842 newly diagnosed and immunophenotypically defined cases of ALL under age 15, and 1986 matched controls in the US. Data regarding day care, sibship size and common childhood infections were obtained through parental interviews. Data were analysed stratified by leukaemia lineage and separately for 'common' childhood ALL (age 2-5 years, CD19, CD10-positive). Neither attendance at day care nor time at day care was associated with risk of ALL overall or 'common' ALL. Ear infections during infancy were less common among cases, with odds ratios of 0.86, 0.83, 0.71 and 0.69 for 1, 2-4, 5+ episodes, and continuous infections respectively (trend P = 0.026). No effect of sibship size or birth interval was seen. With one exception (ear infections), these data do not support the hypothesis that a decrease in the occurrence of common childhood infection increases risk of ALL.

MeSH Terms
Adolescent Birth Intervals Case-Control Studies Child Child Day Care Centers/statistics & numerical data Child, Preschool Demography Family Characteristics Female Humans Immunophenotyping Infant Infant, Newborn Infections/complications,epidemiology Leukemia, B-Cell/epidemiology,etiology Leukemia, T-Cell/epidemiology,etiology Male Odds Ratio Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology,etiology
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Neglia J P
Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, USA.
Linet M S
Shu X O
Severson R K
Potter J D
Mertens A C
Wen W
Kersey J H
Robison L L
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1054/bjoc.1999.0905
Published
2000-01-00
Pages
234-40
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2363184
Subset
IM
Grants
NCI NIH HHS · CA 07036 · United States
NCI NIH HHS · CA 48051 · United States
External Links
PubMed source DOI: 10.1054/bjoc.1999.0905 PMC Full Text View journal details
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