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PMID: 10657296 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cross-species interactions between malaria parasites in humans.

Science (New York, N.Y.) ·Vol. 287 ·No. 5454 ·2000-02-04 ·Pages 845-8

Bruce MC, Donnelly CA, Alpers MP, Galinski MR, Barnwell JW, Walliker D, Day KP

Abstract

The dynamics of multiple Plasmodium infections in asymptomatic children living under intense malaria transmission pressure provide evidence for a density-dependent regulation that transcends species as well as genotype. This regulation, in combination with species- and genotype-specific immune responses, results in nonindependent, sequential episodes of infection with each species.

MeSH Terms

Adolescent Animals Child Child, Preschool Female Genotype Humans Malaria/immunology,parasitology Malaria Vaccines Male Papua New Guinea Parasitemia/parasitology Plasmodium/genetics,physiology Plasmodium falciparum/physiology Plasmodium malariae/physiology Plasmodium vivax/physiology Species Specificity

Chemicals

Malaria Vaccines

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Bruce M C

Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3FY, UK. [email protected]

Donnelly C A

Alpers M P

Galinski M R

Barnwell J W

Walliker D

Day K P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.287.5454.845

[email protected]

Published

2000-02-04

Pages

845-8

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · AI24710 · United States

NIAID NIH HHS · AI37545 · United States

External Links

PubMed source DOI: 10.1126/science.287.5454.845 View journal details

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Cross-species interactions between malaria parasites in humans.

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