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PMID: 1065869 Published · ppublish English Journal Article

Isolation of an inhibitor of DNA synthesis specific for normal and malignant mammary cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 7 ·1976-07-00 ·Pages 2196-200

Gonzalez R, Verly WG

Abstract

A small-molecular-weight inhibitor of DNA synthesis, specific for normal and malignant mammary cells but devoid of species-specificity, has been isolated from bovine mammary glands. This factor has very little effect on RNA metabolism.

MeSH Terms
Animals Carcinoma, Ehrlich Tumor/metabolism Cattle Cells, Cultured Chick Embryo DNA Replication/drug effects Female HeLa Cells/metabolism Mammary Glands, Animal/metabolism Mammary Neoplasms, Experimental/metabolism Orotic Acid/metabolism RNA/metabolism Thymine Nucleotides/metabolism
Chemicals
Thymine Nucleotides Orotic Acid RNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gonzalez R
Verly W G
References (5)
5 references, click to expand
  1. Disk electrophoresis of basic proteins and peptides on polyacrylamide gels.
    Nature. 1962 Jul 21;195:281-3 PMID: 14491328
  2. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  3. Mitotic and functional homeostasis: a speculative review.
    Cancer Res. 1965 Nov;25(10):1683-727 PMID: 5323643
  4. Control of DNA duplication in rat chloroleukaemia by means of the granulocytic chalone.
    Eur J Cancer. 1968 Dec;4(6):595-606 PMID: 5252065
  5. Control of mitosis in rabbit Vx2 epidermal tumours by means of the epidermal chalone.
    Eur J Cancer. 1968 Dec;4(6):587-94 PMID: 5717956
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.7.2196
Published
1976-07-00
Pages
2196-200
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430494
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.7.2196 PMC Full Text View journal details
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