A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).

Journal of medicinal chemistry ·Vol. 43 ·No. 3 ·2000-02-10 ·Pages 342-5

Lovell PJ, Bromidge SM, Dabbs S, Duckworth DM, Forbes IT, Jennings AJ, King FD, Middlemiss DN, Rahman SK, Saunders DV, Collin LL, Hagan JJ, Riley GJ, Thomas DR

Abstract

暂无摘要

MeSH Terms

Cell Line Humans Models, Molecular Phenols/chemical synthesis,chemistry,metabolism Radioligand Assay Receptors, Serotonin/drug effects,metabolism Recombinant Proteins/antagonists & inhibitors,metabolism Serotonin Antagonists/chemical synthesis,chemistry,metabolism Stereoisomerism Structure-Activity Relationship Sulfonamides/chemical synthesis,chemistry,metabolism

Chemicals

Phenols Receptors, Serotonin Recombinant Proteins SB 269970 Serotonin Antagonists Sulfonamides serotonin 7 receptor

Authors & Affiliations

14 authors, click to expand affiliations / ORCID

Lovell P J

SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, U.K. [email protected]

Bromidge S M

Dabbs S

Duckworth D M

Forbes I T

Jennings A J

King F D

Middlemiss D N

Rahman S K

Saunders D V

Collin L L

Hagan J J

Riley G J

Thomas D R

Article Info

Journal

Journal of medicinal chemistry

Abbr.

J Med Chem

ISSN

0022-2623

DOI

10.1021/jm991151j

[email protected]

Published

2000-02-10

Pages

342-5

Language

English

Region

United States

NLM ID

9716531

Subset

External Links

PubMed source DOI: 10.1021/jm991151j View journal details

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A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).

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