Home LiteratureArticle Details
PMID: 10675318 Published · ppublish English Journal Article Review

Multiple pathways control protein kinase C phosphorylation.

The EMBO journal ·Vol. 19 ·No. 4 ·2000-02-15 ·Pages 496-503

Parekh DB, Ziegler W, Parker PJ

Abstract

暂无摘要

MeSH Terms
Amino Acid Sequence Animals Binding Sites Enzyme Activation Humans Isoenzymes/chemistry,genetics,metabolism Models, Biological Molecular Sequence Data Phosphorylation Protein Kinase C/chemistry,genetics,metabolism Protein Structure, Tertiary Sequence Homology, Amino Acid Signal Transduction
Chemicals
Isoenzymes Protein Kinase C
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Parekh D B
Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Ziegler W
Parker P J
References (42)
42 references, click to expand
  1. Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon.
    J Biol Chem. 1999 Dec 3;274(49):34758-64 PMID: 10574945
  2. Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes.
    Biochem J. 1999 Sep 1;342 ( Pt 2):337-44 PMID: 10455020
  3. Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters.
    Proc Natl Acad Sci U S A. 1988 Apr;85(7):2110-4 PMID: 3353368
  4. Autophosphorylation of protein kinase C at three separated regions of its primary sequence.
    Science. 1990 Jul 27;249(4967):408-11 PMID: 2377895
  5. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
    Science. 1991 Jul 26;253(5018):407-14 PMID: 1862342
  6. Studies on the phosphorylation of protein kinase C-alpha.
    Biochem J. 1992 Apr 15;283 ( Pt 2):515-8 PMID: 1575696
  7. Protein kinase C isoenzymes: divergence in signal transduction?
    Biochem J. 1993 Apr 15;291 ( Pt 2):329-43 PMID: 8484714
  8. The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites.
    J Biol Chem. 1993 Aug 5;268(22):16091-4 PMID: 8344891
  9. Protein kinase C--a question of specificity.
    Trends Biochem Sci. 1994 Feb;19(2):73-7 PMID: 8160269
  10. Threonine-497 is a critical site for permissive activation of protein kinase C alpha.
    Biochem J. 1994 Jul 15;301 ( Pt 2):443-8 PMID: 8042986
  11. Requirement for negative charge on "activation loop" of protein kinase C.
    J Biol Chem. 1994 Nov 4;269(44):27715-8 PMID: 7961692
  12. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
    FASEB J. 1995 May;9(8):576-96 PMID: 7768349
  13. Determination of in vivo phosphorylation sites in protein kinase C.
    J Biol Chem. 1995 Nov 10;270(45):26807-12 PMID: 7592921
  14. Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains.
    Mol Cell Biol. 1996 Jan;16(1):405-13 PMID: 8524322
  15. Characterization of the interaction between RhoA and the amino-terminal region of PKN.
    FEBS Lett. 1996 May 6;385(3):221-4 PMID: 8647255
  16. Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin.
    Am J Physiol. 1996 Jul;271(1 Pt 1):C304-11 PMID: 8760059
  17. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations.
    Curr Biol. 1995 Dec 1;5(12):1394-1403 PMID: 8749392
  18. Protein kinase C isozymes and substrates.
    Curr Opin Cell Biol. 1996 Apr;8(2):168-73 PMID: 8791416
  19. Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.
    Curr Biol. 1996 Sep 1;6(9):1114-23 PMID: 8805373
  20. Structural aspects of the functional modules in human protein kinase-C alpha deduced from comparative analyses.
    Proteins. 1996 Oct;26(2):217-35 PMID: 8916229
  21. 12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer.
    J Biol Chem. 1996 Dec 20;271(51):32785-8 PMID: 8955114
  22. Mechanism of activation of protein kinase B by insulin and IGF-1.
    EMBO J. 1996 Dec 2;15(23):6541-51 PMID: 8978681
  23. Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state.
    J Biol Chem. 1997 Feb 7;272(6):3544-9 PMID: 9013603
  24. Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form.
    J Biol Chem. 1997 Mar 7;272(10):6805-11 PMID: 9045715
  25. Regulation of protein kinase C.
    Curr Opin Cell Biol. 1997 Apr;9(2):161-7 PMID: 9069266
  26. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
    Curr Biol. 1997 Apr 1;7(4):261-9 PMID: 9094314
  27. Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C.
    J Biol Chem. 1997 Jul 18;272(29):18382-90 PMID: 9218480
  28. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.
    Science. 1997 Jul 25;277(5325):567-70 PMID: 9228007
  29. The modular phosphorylation and activation of p70s6k.
    FEBS Lett. 1997 Jun 23;410(1):78-82 PMID: 9247127
  30. Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity.
    J Biol Chem. 1997 Sep 26;272(39):24550-5 PMID: 9305920
  31. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
    Curr Biol. 1998 Jan 15;8(2):69-81 PMID: 9427642
  32. Phosphorylation and activation of p70s6k by PDK1.
    Science. 1998 Jan 30;279(5351):707-10 PMID: 9445476
  33. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.
    Science. 1998 Jan 30;279(5351):710-4 PMID: 9445477
  34. Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif.
    J Biol Chem. 1998 Jan 30;273(5):2698-705 PMID: 9446575
  35. PRK1 is targeted to endosomes by the small GTPase, RhoB.
    J Biol Chem. 1998 Feb 27;273(9):4811-4 PMID: 9478917
  36. Loss of protein kinase C function induces an apoptotic response.
    Oncogene. 1998 Apr 16;16(15):1939-44 PMID: 9591777
  37. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
    Science. 1998 Sep 25;281(5385):2042-5 PMID: 9748166
  38. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.
    Curr Biol. 1998 Sep 24;8(19):1069-77 PMID: 9768361
  39. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1).
    Curr Biol. 1998 Dec 17-31;8(25):1366-75 PMID: 9889098
  40. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
    Curr Biol. 1999 Apr 22;9(8):393-404 PMID: 10226025
  41. Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex.
    Curr Biol. 1999 May 20;9(10):522-9 PMID: 10339425
  42. Studies and perspectives of protein kinase C.
    Science. 1986 Jul 18;233(4761):305-12 PMID: 3014651
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/19.4.496
Published
2000-02-15
Pages
496-503
Language
English
Region
England
NLM ID
8208664
PMCID
PMC305587
Subset
IM
External Links
PubMed source DOI: 10.1093/emboj/19.4.496 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2