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PMID: 1067600 Published · ppublish English Journal Article

Influenza virus genome consists of eight distinct RNA species.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 9 ·1976-09-00 ·Pages 3045-9

McGeoch D, Fellner P, Newton C

Abstract

The genomic RNA of the avian influenza A virus, fowl plague, was fractionated into eight species by electrophoresis in polyacrylamide-agarose gels containing 6 M urea. The separated 32P-labeled RNA species were characterized by digestion with RNase T1 and fractionation of the resulting oligonucleotides by two-dimensional gel electrophoresis; this demonstrated that each species has a distinct nucleotide sequence. A tentative correlation of each genome RNA species with the virus protein that it encodes was made.

MeSH Terms
Base Sequence Genes Influenza A virus/analysis Molecular Weight Oligoribonucleotides/analysis RNA, Viral/analysis,isolation & purification Viral Proteins/biosynthesis
Chemicals
Oligoribonucleotides RNA, Viral Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
McGeoch D
Fellner P
Newton C
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23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.9.3045
Published
1976-09-00
Pages
3045-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430922
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.9.3045 PMC Full Text View journal details
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