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PMID: 1067617 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Abnormalities in the glycosphingolipid content of human Pk and p erythrocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 9 ·1976-09-00 ·Pages 3263-7

Marcus DM, Naiki M, Kundu SK

Abstract

Erythrocytes of the rare Pk phenotype lack the blood group P antigen, and p erythrocytes lack both P and Pk antigens. On the basis of immunological data we suggested previously that the P and Pk antigens are the glycosphingolipids globoside and trihexosyl ceramide, respectively, and we have now confirmed these designations by chemical analysis of erythrocytes lacking these antigens. The Pk erythrocytes contain only traces of globoside and have a marked excess of trihexosyl ceramide in comparison with normal erythrocytes. The p erythrocytes lack globoside and trihexosyl ceramide and contain an excess of lactosyl ceramide and other complex glycolipids. Our analyses of normal erythrocytes also revealed complex gangliosides with the approximate chromatographic mobilities of GD1b and GT1, and several gangliosides containing N-acetylglucosamine.

MeSH Terms
Acetylglucosamine/analysis Blood Group Antigens Fatty Acids/analysis Gangliosides/analysis Glycosphingolipids/analysis,immunology Hexoses/analysis Humans P Blood-Group System
Chemicals
Blood Group Antigens Fatty Acids Gangliosides Glycosphingolipids Hexoses P Blood-Group System Acetylglucosamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Marcus D M
Naiki M
Kundu S K
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.9.3263
Published
1976-09-00
Pages
3263-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431001
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.9.3263 PMC Full Text View journal details
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