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PMID: 10679366 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Actin machinery: pushing the envelope.

Current opinion in cell biology ·Vol. 12 ·No. 1 ·2000-02-00 ·Pages 104-12

Borisy GG, Svitkina TM

Abstract

The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility.

MeSH Terms

Actin Depolymerizing Factors Actin-Related Protein 2 Actin-Related Protein 3 Actins/metabolism Animals Contractile Proteins Cytoskeletal Proteins Dendrites/metabolism Destrin Humans Microfilament Proteins/metabolism Models, Biological Molecular Motor Proteins/metabolism Profilins

Chemicals

ACTR2 protein, human ACTR3 protein, human Actin Depolymerizing Factors Actin-Related Protein 2 Actin-Related Protein 3 Actins Contractile Proteins Cytoskeletal Proteins Destrin Microfilament Proteins Molecular Motor Proteins PFN1 protein, human Profilins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Borisy G G

Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA. [email protected]

Svitkina T M

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(99)00063-0

[email protected]

Published

2000-02-00

Pages

104-12

Language

English

Region

England

NLM ID

8913428

Subset

Grants

NIGMS NIH HHS · GM 25062 · United States

External Links

PubMed source DOI: 10.1016/s0955-0674(99)00063-0 View journal details

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Actin machinery: pushing the envelope.

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