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PMID: 10679411 Published · ppublish English Journal Article Review

Tlr4: central component of the sole mammalian LPS sensor.

Current opinion in immunology ·Vol. 12 ·No. 1 ·2000-02-00 ·Pages 20-6

Beutler B

Abstract

Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

MeSH Terms
Alleles Drosophila Proteins Genes, Dominant Genes, Recessive Insect Proteins/genetics Lipopolysaccharide Receptors/genetics,metabolism Lipopolysaccharides/immunology Membrane Glycoproteins/genetics,metabolism Models, Immunological Receptors, Cell Surface/genetics,metabolism Signal Transduction Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors
Chemicals
Drosophila Proteins Insect Proteins Lipopolysaccharide Receptors Lipopolysaccharides Membrane Glycoproteins Receptors, Cell Surface Tl protein, Drosophila Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Beutler B
Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA. [email protected]
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
Published
2000-02-00
Pages
20-6
Language
English
Region
England
NLM ID
8900118
Subset
IM
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