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PMID: 10683395 Published · ppublish English Clinical Trial Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Sex differences in brain-behavior relationships between verbal episodic memory and resting regional cerebral blood flow.

Neuropsychologia ·Vol. 38 ·No. 4 ·2000-00-00 ·Pages 451-61

Ragland JD, Coleman AR, Gur RC, Glahn DC, Gur RE

Abstract

Women have better verbal memory, and higher rates of resting regional cerebral blood flow (rCBF). This study examined whether there are also sex differences in the relationship between verbal episodic memory and resting rCBF. Twenty eight healthy right-handed volunteers (14 male, 14 female) underwent a neuropsychological evaluation and a Positron Emission Tomography (PET) (15)O-water study. Immediate and delayed recall was measured on the logical memory subtest of the Wechsler Memory Scale - Revised (WMS-R), and on the California Verbal Learning Test (CVLT). Resting rCBF (ml/100 g/min) was calculated for four frontal, four temporal, and four limbic regions of interest (ROIs). Women had better immediate recall on both WMS-R and CVLT tasks. Sex differences in rCBF were found for temporal lobe regions. Women had greater bilateral blood flow in a mid-temporal brain region. There were also sex differences in rCBF correlations with performance. Women produced positive correlations with rCBF laterality in the temporal pole. Greater relative CBF in the left temporal pole was associated with better WMS-R immediate and delayed recall in women only. These results suggest that trait differences in temporal pole brain-behavior relationships may relate to sex differences in verbal episodic memory.

MeSH Terms
Adolescent Adult Behavior/physiology Brain/diagnostic imaging,physiology Cerebrovascular Circulation/physiology Female Frontal Lobe/blood supply,diagnostic imaging,physiology Functional Laterality/physiology Humans Male Memory/physiology Memory, Short-Term/physiology Neuropsychological Tests Sex Characteristics Temporal Lobe/blood supply,diagnostic imaging,physiology Tomography, Emission-Computed Verbal Behavior/physiology Visual Perception/physiology
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ragland J D
Department of Psychiatry, University of Pennsylvania Health Systems, 10th Floor, Gates Building, 3400 Spruce Street, Philadelphia 19104-4283, USA. [email protected]
Coleman A R
Gur R C
Glahn D C
Gur R E
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Article Info
Journal
Neuropsychologia
Abbr.
Neuropsychologia
ISSN
0028-3932
DOI
10.1016/s0028-3932(99)00086-x
Email
[email protected]
Published
2000-00-00
Pages
451-61
Language
English
Region
England
NLM ID
0020713
PMCID
PMC4334366
Subset
IM
Grants
NIMH NIH HHS · T32 MH019112 · United States
NIMH NIH HHS · MH-00586 · United States
NIMH NIH HHS · MH-48539 · United States
NIMH NIH HHS · R01 MH062103 · United States
NIMH NIH HHS · MH-19112 · United States
External Links
PubMed source DOI: 10.1016/s0028-3932(99)00086-x PMC Full Text View journal details
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