Circadian rhythms: new functions for old clock genes.

Trends in genetics : TIG ·Vol. 16 ·No. 3 ·2000-03-00 ·Pages 135-42

Lakin-Thomas PL

Abstract

The mechanisms of circadian clocks, which time daily events, are being investigated by characterizing 'clock genes' that affect daily rhythms. The core of the clock mechanism in Drosophila, Neurospora, mammals and cyanobacteria is described by a transcription-translation feedback-loop model. However, problems with this model could indicate that it is time to look at the functions of these genes in a different light. Our a priori assumptions about the nature of circadian clocks might have restricted our search for new mutants in ways that prevent us from finding important clock genes.

MeSH Terms

Acetabularia/genetics Animals Circadian Rhythm/genetics Cyanobacteria/genetics Drosophila melanogaster/genetics Feedback Gene Expression Regulation Gene Expression Regulation, Fungal Genes, Bacterial Genes, Fungal Genes, Plant Humans Mammals/genetics Mice Models, Biological Models, Genetic Mutagenesis Neurospora crassa/genetics Protein Biosynthesis Protein Structure, Tertiary/genetics Transcription, Genetic

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lakin-Thomas P L

Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge UK. [email protected]

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

DOI

10.1016/s0168-9525(99)01945-9

[email protected]

Published

2000-03-00

Pages

135-42

Language

English

Region

England

NLM ID

8507085

Subset

External Links

PubMed source DOI: 10.1016/s0168-9525(99)01945-9 View journal details

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