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PMID: 1069306 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Infinite allele model with varying mutation rate.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 11 ·1976-11-00 ·Pages 4164-8

Nei M, Chakraborty R, Fuerst PA

Abstract

Available data suggest that the variation in mutation rate among protein loci follows the gamma distribution. Thus, taking into account this variation, formulae are developed for the distribution of allele frequencies, mean and variance of heterozygosity, expected number of alleles, proportion of polymorphic loci, and genetic distance. These formulae should be more appropriate for the analysis of gene frequency data for protein loci than equivalent formulae with constant mutation rate.

MeSH Terms
Alleles Gene Frequency Heterozygote Models, Biological Mutation Polymorphism, Genetic
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nei M
Chakraborty R
Fuerst P A
References (12)
12 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.11.4164
Published
1976-11-00
Pages
4164-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431369
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.11.4164 PMC Full Text View journal details
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