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PMID: 1069452 Published · ppublish English Journal Article

Morphology and DNA content of endometrial cancer nuclei under progestogen treatment.

Acta cytologica ·Vol. 20 ·No. 6 ·1976-00-00 ·Pages 556-8

Hustin J

Abstract

Twelve endometrial cancers have been observed before and during progestogen treatment. Eight were well-differentiated and displayed an objective response. It was essentially characterized by a volumetric reduction of the nucleus and the disappearance of tetraploid nuclei. The DNA content remained diploid or near-diploid. Reduction of nuclear non DNA proteins under hormonal treatment is suggested.

Keywords
Biology Cancer Clinical Research Cytologic Effects Diseases Endocrine System Endometrial Cancer Genitalia Genitalia Female Hormones Neoplasms Physiology Progestational Hormones Progesterone--side effects Progesterone--therapeutic use Research Methodology Urogenital System Uterus
MeSH Terms
Cell Nucleus/analysis,ultrastructure DNA, Neoplasm/analysis Female Humans Lynestrenol/therapeutic use Uterine Neoplasms/analysis,drug therapy,ultrastructure
Chemicals
DNA, Neoplasm Lynestrenol
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hustin J
Other Abstracts
eng

Morphology and deoxyribonucleic acid (DNA) content of endometrial cancer nuclei under progestogen treatment are reported. 12 endometrial cancers were observed before and during treatment. 8 were well-differentiated and displayed on objective response. The response was characterized by a volumetric reduction of the nucleus and the disappearance of tetraploid nuclei. DNA content remained diploid or near-diploid. Reduction of nuclear non-DNA proteins in endometrial cancers under progestogen treatment is suggested.

Article Info
Journal
Acta cytologica
Abbr.
Acta Cytol
ISSN
0001-5547
Published
1976-00-00
Pages
556-8
Language
English
Region
Switzerland
NLM ID
0370307
Subset
IM
External Links
PubMed source View journal details
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