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PMID: 10694886 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Eukaryotic DNA polymerases, a growing family.

Trends in biochemical sciences ·Vol. 25 ·No. 3 ·2000-03-00 ·Pages 143-7

Hübscher U, Nasheuer HP, Syväoja JE

Abstract

In eukaryotic cells, DNA polymerases are required to maintain the integrity of the genome during processes, such as DNA replication, various DNA repair events, translesion DNA synthesis, DNA recombination, and also in regulatory events, such as cell cycle control and DNA damage checkpoint function. In the last two years, the number of known DNA polymerases has increased to at least nine (called alpha, beta, gamma, delta, epsilon, zeta, eta, t and iota), and yeast Saccharomyces cerevisiae contains REV1 deoxycytidyl transferase.

MeSH Terms
Animals DNA/biosynthesis DNA Polymerase III/metabolism DNA Polymerase beta/metabolism DNA-Directed DNA Polymerase/metabolism Eukaryotic Cells/enzymology Fungal Proteins/metabolism Humans Nucleotidyltransferases Saccharomyces cerevisiae Proteins
Chemicals
Fungal Proteins Saccharomyces cerevisiae Proteins DNA DNA polymerase iota DNA polymerase theta Nucleotidyltransferases REV1 protein, S cerevisiae DNA Polymerase III DNA Polymerase beta DNA-Directed DNA Polymerase Rad30 protein
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hübscher U
Institute of Veterinary Biochemistry, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. [email protected]
Nasheuer H P
Syväoja J E
Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
Published
2000-03-00
Pages
143-7
Language
English
Region
England
NLM ID
7610674
Subset
IM
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