Home LiteratureArticle Details
PMID: 10712945 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

B-1 cells: orthodox or conformist?

Current opinion in immunology ·Vol. 12 ·No. 2 ·2000-04-00 ·Pages 191-4

Su I, Tarakhovsky A

Abstract

B-1 cells differ from conventional peripheral B cells (B-2) by anatomical location, surface marker expression, antibody repertoire and growth properties. The lineage hypothesis of B-1 cell development attributes the properties of B-1 cells to their unique origin. The induced differentiation hypothesis suggests the surface-immunoglobulin-driven development of B-1 cells from common B-1/B-2 cell progenitors. In both models self-antigen-induced signalling plays the central role in positive selection of B-1 cells. The ability of B-1 cells to be positively selected by self-antigens raises questions about the mechanism of this phenomenon.

MeSH Terms
Animals Antigens, Differentiation, B-Lymphocyte/immunology Autoantibodies/biosynthesis Autoantigens/immunology Autoimmunity B-Lymphocyte Subsets/drug effects,immunology CD5 Antigens/immunology Cell Differentiation Cell Lineage Clonal Deletion Gene Rearrangement, B-Lymphocyte, Heavy Chain Hematopoietic Stem Cells/cytology Humans Immunoglobulin Heavy Chains/genetics Lymphocyte Activation/drug effects Mice Mice, Transgenic Models, Immunological Phorbol Esters/pharmacology Receptors, Antigen, B-Cell/genetics,immunology Signal Transduction Thy-1 Antigens/genetics,immunology
Chemicals
Antigens, Differentiation, B-Lymphocyte Autoantibodies Autoantigens CD5 Antigens Immunoglobulin Heavy Chains Phorbol Esters Receptors, Antigen, B-Cell Thy-1 Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Su I
Laboratory of Lymphocyte Signaling, Institute for Genetics, University of Köln, Köln, D-50931, Germany.
Tarakhovsky A
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/s0952-7915(99)00071-0
Published
2000-04-00
Pages
191-4
Language
English
Region
England
NLM ID
8900118
Subset
IM
External Links
PubMed source DOI: 10.1016/s0952-7915(99)00071-0 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2