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PMID: 10720332 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Rapid extragranular plasticity in the absence of thalamocortical plasticity in the developing primary visual cortex.

Science (New York, N.Y.) ·Vol. 287 ·No. 5460 ·2000-03-17 ·Pages 2029-32

Trachtenberg JT, Trepel C, Stryker MP

Abstract

Monocular deprivation during early postnatal development remodels the circuitry of the primary visual cortex so that most neurons respond poorly to stimuli presented to the deprived eye. This rapid physiological change is ultimately accompanied by a matching anatomical loss of input from the deprived eye. This remodeling is thought to be initiated at the thalamocortical synapse. Ocular dominance plasticity after brief (24 hours) monocular deprivation was analyzed by intrinsic signal optical imaging and by targeted extracellular unit recordings. Deprived-eye responsiveness was lost in the extragranular layers, whereas normal binocularity in layer IV was preserved. This finding supports the hypothesis that thalamocortical organization is guided by earlier changes at higher stages.

MeSH Terms
Animals Brain Mapping Cats Microelectrodes Neuronal Plasticity Neurons/physiology Photic Stimulation Thalamus/anatomy & histology,growth & development,physiology Vision, Binocular Vision, Monocular Visual Cortex/anatomy & histology,growth & development,physiology Visual Pathways/anatomy & histology,physiology Visual Perception
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Trachtenberg J T
W. M. Keck Foundation Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, CA 94143-0444, USA.
Trepel C
Stryker M P
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.287.5460.2029
Published
2000-03-17
Pages
2029-32
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2412909
Subset
IM
Grants
NEI NIH HHS · EY06824 · United States
NEI NIH HHS · R37-EY02874 · United States
NEI NIH HHS · R37 EY002874 · United States
NEI NIH HHS · R37 EY002874-21 · United States
NEI NIH HHS · F32 EY006824 · United States
External Links
PubMed source DOI: 10.1126/science.287.5460.2029 PMC Full Text View journal details
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